Trousseau sign of malignancy
| Trousseau sign of malignancy |
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Overview
The Trousseau sign of malignancy is a medical sign commonly found in certain cancers. It is also referred to as Trousseau syndrome and is distinct from the Trousseau sign of latent tetany.
Some malignancies, especially adenocarcinomas of the pancreas and lung, are associated with hypercoagulability (the tendency to form blood clots) for reasons that are incompletely understood, but may be related to factors secreted by the tumors. In patients with malignancy-associated hypercoagulable states, the blood may spontaneously form clots in the portal vessels, the deep veins of the extremities (such as the leg), or the superficial veins anywhere on the body. These clots present as visibly swollen blood vessels (vasculitis), especially the veins, or as intermittent pain in the affected areas. The pathological phenomenon of clots forming, resolving and then appearing again elsewhere in the body has been named thrombophlebitis migrans or migratory thrombophlebitis.
Armand Trousseau first described this finding in himself; he was subsequently diagnosed with pancreatic cancer.
Complete Differential Diagnosis of the Causes of Trousseau Sign of Malignancy
(In alphabetical order)
Migratory thrombophlebitis:
Complete Differential Diagnosis of the Causes of Trousseau Sign of Malignancy:
(By organ system)
| Cardiovascular | No underlying causes |
| Chemical / poisoning | No underlying causes |
| Dermatologic | No underlying causes |
| Drug Side Effect | No underlying causes |
| Ear Nose Throat | No underlying causes |
| Endocrine | No underlying causes |
| Environmental | No underlying causes |
| Gastroenterologic | Colon cancer, Gastric carcinoma, Pancreatic cancer |
| Genetic | No underlying causes |
| Hematologic | No underlying causes |
| Iatrogenic | No underlying causes |
| Infectious Disease | No underlying causes |
| Musculoskeletal / Ortho | No underlying causes |
| Neurologic | No underlying causes |
| Nutritional / Metabolic | No underlying causes |
| Obstetric/Gynecologic | Ovarian cancer |
| Oncologic | Colon cancer, Gastric carcinoma, Lung cancer, Pancreatic cancer, Ovarian cancer |
| Opthalmologic | No underlying causes |
| Overdose / Toxicity | No underlying causes |
| Psychiatric | No underlying causes |
| Pulmonary | Lung cancer |
| Renal / Electrolyte | No underlying causes |
| Rheum / Immune / Allergy | No underlying causes |
| Sexual | No underlying causes |
| Trauma | No underlying causes |
| Urologic | No underlying causes |
| Miscellaneous | No underlying causes |
See also
Template:Skin and subcutaneous tissue symptoms and signs Template:Nervous and musculoskeletal system symptoms and signs Template:Urinary system symptoms and signs Template:Cognition, perception, emotional state and behaviour symptoms and signs Template:Speech and voice symptoms and signs Template:General symptoms and signs
- ↑ Morgun IF (1969). "[Migrating thrombophlebitis in gastric cancer]". Vrach Delo (in Russian). 5: 135–7. PMID 5368868. Unknown parameter
|month=ignored (help) - ↑ Kukhtevich AV, Russkikh AV, Kuznetsova AI, Gorbacheva EN (1999). "[Paraneoplastic syndrome (fever, anemia, migrating thrombophlebitis) in ovarian cancer]". Ter. Arkh. (in Russian). 71 (10): 46–8. PMID 10612175.