Postpartum hemorrhage

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Adnan Ezici, M.D [2]

Synonyms and keywords:

Overview

Historical Perspective

In 1953, du Vigneaud et al. and Tuppy were the first to discover the aminoacid sequence of oxytocin and its biochemical synthesis.^[1]
In 1962, the use of prophylactic uterotonic agent, early cord clamping, and controlled cord traction were defined by Spencer for the active management of the third stage of labor (AMTSL).^[2]
The reduction of postpartum hemorrhage by the active management of the third stage of labor (AMTSL) compared to the physiological (expectant) management was established by Prendiville et al. in 1988 following a randomized controlled trial.^[3]
In 1997, the B-Lynch surgical technique was developed by B-Lynch et al. to treat postpartum hemorrhage.^[4]
In 2005, first placebo-controlled study of misoprostol was conducted by Derman et al. for the prevention of postpartum hemorrhage.^[5]
In 2007, the use of misoprostol in the absence of oxytocin was recommended by World Health Organization (WHO) for the prevention of postpartum hemorrhage.^[1]

Classification

Postpartum hemorrhage is classified according to the duration between the delivery and hemorrhage into 2 groups: primary and secondary.^[6]

If the postpartum hemorrhage begins within the first 24 hours after birth, it is classified as primary postpartum hemorrhage.
If the postpartum hemorrhage occurs between 24 hours and 12 weeks after birth, it is classified as secondary postpartum hemorrhage.

Pathophysiology

The pathophysiology of postpartum hemorrhage depends on the underlying etiology:

Inadequate contractions following the delivery (uterine atony)^[7]
Trauma in either vulva, vagina, or cervix during the delivery (obstetrical lacerations)^[8]
Placenta accreta, increta, percreta, or incomplete delivery of placenta (retained placental tissue)^[6]
Massive activation of the coagulation system and subsequent consumption of the coagulation factors (disseminated intravascular coagulation), platelet disorders (thrombocytopenia caused by preeclampsia, HELLP syndrome, ITP, TTP, acute fatty liver of pregnancy and HUS, and also qualitative platelet disorders), von Willebrand disease (vWD), hemophilia A, and hemophilia B (maternal coagulation disorders) ^[9]

Causes

The most common cause of postpartum hemorrhage is uterine atony. Less common causes of postpartum hemorrhage include obstetrical lacerations, retained placental tissue, and maternal coagulation disorders.^[6]

Differentiating ((Page name)) from other Diseases

[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].

References

↑ ^1.0 ^1.1 Prata N, Bell S, Weidert K (2013). "Prevention of postpartum hemorrhage in low-resource settings: current perspectives". Int J Womens Health. 5: 737–52. doi:10.2147/IJWH.S51661. PMC 3833941. PMID 24259988.
↑ Hofmeyr GJ, Mshweshwe NT, Gülmezoglu AM (January 2015). "Controlled cord traction for the third stage of labor". Cochrane Database Syst Rev. 1: CD008020. doi:10.1002/14651858.CD008020.pub2. PMC 6464177. PMID 25631379.
↑ Prendiville WJ, Harding JE, Elbourne DR, Stirrat GM (November 1988). "The Bristol third stage trial: active versus physiological management of third stage of labour". BMJ. 297 (6659): 1295–300. doi:10.1136/bmj.297.6659.1295. PMC 1834913. PMID 3144366.
↑ El-Hamamy E, Wright A, B-Lynch C (May 2009). "The B-Lynch suture technique for postpartum haemorrhage: a decade of experience and outcome". J Obstet Gynaecol. 29 (4): 278–83. doi:10.1080/01443610902797645. PMID 19835492.
↑ Derman RJ, Kodkany BS, Goudar SS, Geller SE, Naik VA, Bellad MB, Patted SS, Patel A, Edlavitch SA, Hartwell T, Chakraborty H, Moss N (October 2006). "Oral misoprostol in preventing postpartum haemorrhage in resource-poor communities: a randomised controlled trial". Lancet. 368 (9543): 1248–53. doi:10.1016/S0140-6736(06)69522-6. PMID 17027730.
↑ ^6.0 ^6.1 ^6.2 Bienstock JL, Eke AC, Hueppchen NA (2021). "Postpartum Hemorrhage". N Engl J Med. 384 (17): 1635–1645. doi:10.1056/NEJMra1513247. PMID 33913640 Check |pmid= value (help).
↑ Breathnach F, Geary M (2009). "Uterine atony: definition, prevention, nonsurgical management, and uterine tamponade". Semin Perinatol. 33 (2): 82–7. doi:10.1053/j.semperi.2008.12.001. PMID 19324236.
↑ "ACOG Practice Bulletin No. 198: Prevention and Management of Obstetric Lacerations at Vaginal Delivery". Obstet Gynecol. 132 (3): e87–e102. September 2018. doi:10.1097/AOG.0000000000002841. PMID 30134424.
↑ Silver RM, Major H (March 2010). "Maternal coagulation disorders and postpartum hemorrhage". Clin Obstet Gynecol. 53 (1): 252–64. doi:10.1097/GRF.0b013e3181cef930. PMID 20142661.

Template:WikiDoc Sources

[pmid24259988-1] 1.0 ^1.1 Prata N, Bell S, Weidert K (2013). "Prevention of postpartum hemorrhage in low-resource settings: current perspectives". Int J Womens Health. 5: 737–52. doi:10.2147/IJWH.S51661. PMC 3833941. PMID 24259988.

[pmid25631379-2] Hofmeyr GJ, Mshweshwe NT, Gülmezoglu AM (January 2015). "Controlled cord traction for the third stage of labor". Cochrane Database Syst Rev. 1: CD008020. doi:10.1002/14651858.CD008020.pub2. PMC 6464177. PMID 25631379.

[pmid3144366-3] Prendiville WJ, Harding JE, Elbourne DR, Stirrat GM (November 1988). "The Bristol third stage trial: active versus physiological management of third stage of labour". BMJ. 297 (6659): 1295–300. doi:10.1136/bmj.297.6659.1295. PMC 1834913. PMID 3144366.

[pmid19835492-4] El-Hamamy E, Wright A, B-Lynch C (May 2009). "The B-Lynch suture technique for postpartum haemorrhage: a decade of experience and outcome". J Obstet Gynaecol. 29 (4): 278–83. doi:10.1080/01443610902797645. PMID 19835492.

[pmid17027730-5] Derman RJ, Kodkany BS, Goudar SS, Geller SE, Naik VA, Bellad MB, Patted SS, Patel A, Edlavitch SA, Hartwell T, Chakraborty H, Moss N (October 2006). "Oral misoprostol in preventing postpartum haemorrhage in resource-poor communities: a randomised controlled trial". Lancet. 368 (9543): 1248–53. doi:10.1016/S0140-6736(06)69522-6. PMID 17027730.

[pmid33913640-6] 6.0 ^6.1 ^6.2 Bienstock JL, Eke AC, Hueppchen NA (2021). "Postpartum Hemorrhage". N Engl J Med. 384 (17): 1635–1645. doi:10.1056/NEJMra1513247. PMID 33913640 Check |pmid= value (help).

[pmid19324236-7] Breathnach F, Geary M (2009). "Uterine atony: definition, prevention, nonsurgical management, and uterine tamponade". Semin Perinatol. 33 (2): 82–7. doi:10.1053/j.semperi.2008.12.001. PMID 19324236.

[pmid30134424-8] "ACOG Practice Bulletin No. 198: Prevention and Management of Obstetric Lacerations at Vaginal Delivery". Obstet Gynecol. 132 (3): e87–e102. September 2018. doi:10.1097/AOG.0000000000002841. PMID 30134424.

[pmid20142661-9] Silver RM, Major H (March 2010). "Maternal coagulation disorders and postpartum hemorrhage". Clin Obstet Gynecol. 53 (1): 252–64. doi:10.1097/GRF.0b013e3181cef930. PMID 20142661.

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