Thin basement membrane disease natural history, complications and prognosis
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Overview
Natural history, complications and prognosis
Natural History
- The symptoms of TBMD are usually developed in first decade of life and start with symptoms such as recurrent hematuria. It occurs rarely after age 50 years.
- The symptoms of TBMD typically are not present initially, are found incidentally as microscopic hematuria, mild proteinuria in routine urine analysis and macroscopic hematuria rarely.[1]
- If left untreated, adult TBMD patients with proteinuria may develop hypertension, renal impairment leading to renal insufficiency. [2]
Complication
Common complications of TBMD include[2]:
- Hypertension.
- Proteinuria.
- Renal impairment.
- Renal failure.
- Anxiety.
Prognosis
- Prognosis is good in patient with isolated hematuria.
- The presence of proteinuria or other glomerulopathy is associated with a particularly poor prognosis among patients with TBMD.[3][4]
References
- ↑ Zurawski J, Salwa-Zurawska W, Woźniak A, Bortkiewicz E, Maciejewski J, Idasiak-Piechocka I, Urbański B (2009). "Clinical and morphological aspects of thin glomerular basement membrane disease". Pol J Pathol. 60 (1): 35–42. PMID 19670702.
- ↑ 2.0 2.1 Tonna S, Wang YY, MacGregor D, Sinclair R, Martinello P, Power D, Savige J (May 2005). "The risks of thin basement membrane nephropathy". Semin Nephrol. 25 (3): 171–5. doi:10.1016/j.semnephrol.2005.01.009. PMID 15880328.
- ↑ Hashimoto H, Ohashi N, Tsuji N, Naito Y, Isobe S, Fujikura T, Tsuji T, Kato A, Nozu K, Iijima K, Yasuda H (July 2019). "A case report of thin basement membrane nephropathy accompanied by sporadic glomerulocystic kidney disease". BMC Nephrol. 20 (1): 248. doi:10.1186/s12882-019-1451-6. PMC 6617628 Check
|pmc=
value (help). PMID 31288791. - ↑ Norby SM, Cosio FG (May 2005). "Thin basement membrane nephropathy associated with other glomerular diseases". Semin Nephrol. 25 (3): 176–9. doi:10.1016/j.semnephrol.2005.01.010. PMID 15880329.