Thin basement membrane disease natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Marufa Marium, M.B.B.S[2]
Overview
TBMD is may developed or found incidentally in first decade of life in symptomatic patient, may present symptoms later in third decade in asymptomatic patient. If left untreated, adult TBMD patients with proteinuria may develop hypertension, renal impairment leading to renal insufficiency. Prognosis is usually good in patient with isolated hematuria in TBMD.
Natural history, complications and prognosis
Natural History
- The symptoms of TBMD are usually developed in first decade of life and start with symptoms such as recurrent hematuria. It occurs rarely after age 50 years.
- The symptoms of TBMD typically are not present initially, are found incidentally as microscopic hematuria, mild proteinuria in routine urine analysis and macroscopic hematuria rarely.[1]
- If left untreated, adult TBMD patients with proteinuria may develop hypertension, renal impairment leading to renal insufficiency. [2]
Complication
Common complications of TBMD include[2]:
- Hypertension.
- Proteinuria.
- Renal impairment.
- Renal failure.
- Anxiety.
Prognosis
- Prognosis is good in patient with isolated hematuria.
- The presence of proteinuria or other glomerulopathy is associated with a particularly poor prognosis among patients with TBMD.[3][4]
References
- ↑ Zurawski J, Salwa-Zurawska W, Woźniak A, Bortkiewicz E, Maciejewski J, Idasiak-Piechocka I, Urbański B (2009). "Clinical and morphological aspects of thin glomerular basement membrane disease". Pol J Pathol. 60 (1): 35–42. PMID 19670702.
- ↑ 2.0 2.1 Tonna S, Wang YY, MacGregor D, Sinclair R, Martinello P, Power D, Savige J (May 2005). "The risks of thin basement membrane nephropathy". Semin Nephrol. 25 (3): 171–5. doi:10.1016/j.semnephrol.2005.01.009. PMID 15880328.
- ↑ Hashimoto H, Ohashi N, Tsuji N, Naito Y, Isobe S, Fujikura T, Tsuji T, Kato A, Nozu K, Iijima K, Yasuda H (July 2019). "A case report of thin basement membrane nephropathy accompanied by sporadic glomerulocystic kidney disease". BMC Nephrol. 20 (1): 248. doi:10.1186/s12882-019-1451-6. PMC 6617628 Check
|pmc=value (help). PMID 31288791. - ↑ Norby SM, Cosio FG (May 2005). "Thin basement membrane nephropathy associated with other glomerular diseases". Semin Nephrol. 25 (3): 176–9. doi:10.1016/j.semnephrol.2005.01.010. PMID 15880329.