Coronavirus historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aditya Govindavarjhulla, M.B.B.S. [2]
Overview
Coronaviruses were first isolated from chickens in 1937. In 1965, Tyrrell and Bynoe used cultures of human ciliated embryonal trachea to propagate the first human coronavirus (HCoV) in vitro. There are now approximately 15 species in this family, which infect not only man but cattle, pigs, rodents, cats, dogs and birds (some are serious veterinary pathogens, especially chickens).
Historical Perspective
- Coronaviruses were first isolated from chickens in 1937.
- In 1965, Tyrrell and Bynoe used cultures of human ciliated embryonal trachea to propagate the first human coronavirus (HCoV) in vitro.
- There are now approximately 15 species in this family, which infect not only man but cattle, pigs, rodents, cats, dogs and birds (some are serious veterinary pathogens, especially chickens).[1]
- The virus gained international popularity after the deadly SARS epidemic caused by SARS-CoV in 2002 - 2003.
- Prior to the SARS epidemic, two coronaviruses (HCoV-OC43 and HCoV-229E) were recognized to be responsible for causing upper respiratory tract infections with more severe outcomes in the elderly and the immunocompromised.[2]
- SARS-CoV however, not only caused severe respiratory illness with a mortality rate of 10% during the 2002 - 2003 epidemic but it also caused systemic disease affecting other organs and tissues.
References
- ↑ Garbino J, Crespo S, Aubert JD, Rochat T, Ninet B, Deffernez C, Wunderli W, Pache JC, Soccal PM, Kaiser L (October 2006). "A prospective hospital-based study of the clinical impact of non-severe acute respiratory syndrome (Non-SARS)-related human coronavirus infection". Clin. Infect. Dis. 43 (8): 1009–15. doi:10.1086/507898. PMID 16983613.