Familial adenomatous polyposis epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2], Mohamad Alkateb, MBBCh [3]

Overview

The incidence familial adenomatous polyposis is approximately 12 per 100,000 births in the Europe.^[1]

The prevalence of familial adenomatous polyposis is approximately 10-20 per 100,000 individuals.^[2]
The prevalence of familial adenomatous polyposis is approximately 3-10 per 100,000 individuals in the Europe.^[1]

In 1975, the incidence of familial adenomatous polyposis is approximately 13 per 100,000 individuals with a surgical mortality rate of 4.4% in Sweden.^[3]

Patients in their first and second decades usually develop familial adenomatous polyposis.
100% of patients with familial adenomatous polyposis without treatment will develop colorectal cancer by age of 39.^[4]
The incidence of [disease name] increases with age; the median age at diagnosis is [#] years.

There is no racial predilection to [disease name].
[Disease name] usually affects individuals of the [race 1] race. [Race 2] individuals are less likely to develop [disease name].

↑ ^1.0 ^1.1 ^1.2 Half, Elizabeth; Bercovich, Dani; Rozen, Paul (2009). "Familial adenomatous polyposis". Orphanet Journal of Rare Diseases. 4 (1): 22. doi:10.1186/1750-1172-4-22. ISSN 1750-1172.
↑ Nieuwenhuis, M.H.; Vasen, H.F.A. (2007). "Correlations between mutation site in APC and phenotype of familial adenomatous polyposis (FAP): A review of the literature". Critical Reviews in Oncology/Hematology. 61 (2): 153–161. doi:10.1016/j.critrevonc.2006.07.004. ISSN 1040-8428.
↑ Alm T (1975). "Surgical treatment of hereditary adenomatosis of the colon and rectum in Sweden during the last 20 years. Part II. Patients with prophylactic operations, primary and late results. Discussion and summary". Acta Chir Scand. 141 (3): 228–37.
↑ Beech D, Pontius A, Muni N, Long WP (2001). "Familial adenomatous polyposis: a case report and review of the literature". J Natl Med Assoc. 93 (6): 208–13. PMC 2594024. PMID 11446392.