Chronic myelogenous leukemia staging

Chronic myelogenous leukemia Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Chronic myelogenous leukemia from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
Staging
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
Chest X Ray
CT
MRI
Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Chronic myelogenous leukemia staging On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Chronic myelogenous leukemia staging All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Chronic myelogenous leukemia staging
CDC on Chronic myelogenous leukemia staging
Chronic myelogenous leukemia staging in the news
Blogs on Chronic myelogenous leukemia staging
Directions to Hospitals Treating Chronic myelogenous leukemia
Risk calculators and risk factors for Chronic myelogenous leukemia staging

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]

Overview

Chronic myelogenous leukemia may be classified according to the clinical characteristics and laboratory findings into three subtypes: chronic phase, accelerated phase, and blast crisis.

Classification

Chronic myelogenous leukemia is often divided into three phases based on clinical characteristics and laboratory findings.

Phases	Associations
Chronic phase	Most patients (85%) are diagnosed in this phase Less than 10% of cells in the blood and bone marrow are blasts Usually asymptomatic or mild symptoms my present Progress slowly Respond well to treatment
Accelerated phase	According to the World Health Organization diagnostic criteria, patient is considered to be in the accelerated phase if any of the following is present: 10–19% myeloblasts in the blood or bone marrow >20% basophils in the blood or bone marrow Platelet count <100,000, unrelated to therapy Platelet count >1,000,000, unresponsive to therapy Cytogenetic evolution with new abnormalities in addition to the Philadelphia chromosome Splenomegaly or increasing white blood cell count, unresponsive to therapy
Blast or acute phase	Disease acts more like an acute leukemia 30% of cells in blood and bone marrow are blast Blast cells often spread to tissues and organs outside the bone marrow Usually symptomatic Bleeding and infections are common Blast crisis may occur The accelerated phase can change quickly into the blast phase with symptoms of fever, malaise, and splenomegaly

References

Template:WikiDoc Sources