Retinoblastoma risk factors
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Retinoblastoma Microchapters |
Diagnosis |
---|
Treatment |
Case Studies |
Retinoblastoma risk factors On the Web |
American Roentgen Ray Society Images of Retinoblastoma risk factors |
Risk calculators and risk factors for Retinoblastoma risk factors |
Overview
Common risk factors in the development of retinoblastoma are, advanced paternal age, positive family history, and viral exposure.
Common Risk Factors
Family History
Approximately 10% of patients with retinoblastoma have a previously established family history of the disease.
Viral exposure
The presence of HPV sequences in retinoblastoma tumor tissue may play a role in the development of sporadic retinoblastoma.
Advanced paternal age
There is evidence suggesting that the mutations of RB1 are more common during spermatogenesis than oogenesis.[1]
See also
References
- ↑ Dryja, Thaddeus P.; Mukai, Shizuo; Petersen, Robert; Rapaport, Joyce M.; Walton, David; Yandell, David W. (1989). "Parental origin of mutations of the retinoblastoma gene". Nature. 339 (6225): 556–558. doi:10.1038/339556a0. ISSN 0028-0836.