Retinoblastoma risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]

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Overview

Common risk factors in the development of retinoblastoma are, advanced paternal age, positive family history, and viral exposure.

Common Risk Factors

Family History

Approximately 10% of patients with retinoblastoma have a previously established family history of the disease.

Viral exposure

The presence of HPV sequences in retinoblastoma tumor tissue may play a role in the development of sporadic retinoblastoma.

Advanced paternal age

There is evidence suggesting that the mutations of RB1 are more common during spermatogenesis than oogenesis.[1]


See also

References

  1. Dryja, Thaddeus P.; Mukai, Shizuo; Petersen, Robert; Rapaport, Joyce M.; Walton, David; Yandell, David W. (1989). "Parental origin of mutations of the retinoblastoma gene". Nature. 339 (6225): 556–558. doi:10.1038/339556a0. ISSN 0028-0836.


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