Non-Hodgkin lymphoma pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: {{AS}]
Overview
Pathophysiology
B cell lymphomas
Name | Size of cells | Site | Histomorphology | IHC | Translocations |
---|---|---|---|---|---|
Follicular lymphoma | small (centrocytes) | lymph node, germinal center | abundant atypical follicles (lack GC polarity, lack polar mantle zone), effaced sinuses, scattered large cells (centroblasts) | CD10+, bcl-6+[1] | t(14,18) |
Mantle cell lymphoma | small, monomorphic | lymph node, mantle zone | monomorphic lymphoid, abundant mitoses. +/-scattered epithelioid histiocytes, sclerosed blood vessels | CD5+, CD23-, CD43+, cyclin D1+[1] | t(11;14)(q13;q32)[2] |
Extranodal marginal zone lymphoma (MALT lymphoma) | small | mucosa-associated lymphoid tissue, GI tract + elsewhere | +/- lymphepithelial lesion (cluster of 3+ cells in epithelium) | CD21+, CD11c+, CD5-, CD23-[1] | ---------- |
Precursor B-cell lymphoblastic lymphoma/ leukemia | small | lymph node ???, bone marrow | nuclei slightly large than resting lymphocytes, scant basophilic cytoplasm, irregular nuclear membrane, no nucleoli, stippled chromatin[3] | CD10+, CD5-, TdT+, CD99+[1] | +/-t(12;21)[4] |
Hairy cell leukemia | small | bone marrow, peripheral blood | perinuclear clearing, clear cytoplasm, central nucleus | CD25+, CD103+, CD5-[5] | ---------- |
Burkitt's lymphoma | medium, monomorphic | lymph node, germinal center (???) | tingible-body macrophages ("starry sky" appearance), round nucleus, small nucleoli, mitoses +++ | CD10+, BCL6+, BCL2- | t(8;14) (q24;q32) |
Diffuse large B cell lymphoma | large cells (>2x RBC, often larger), variable size | lymph node usually, germinal center | sheets of large discohesive cells; if only nodular = follicular lymphoma | MIB1 >40% | none / like follicular lymphoma t(14,18) / c-MYC (like Burkitt lymphoma) |
Primary mediastinal B-cell lymphoma | large (>2x RBC, often larger), variable size | mediastinum | ---------- | ---------- | ---------- |
B cell small lymphocytic lymphoma / chronic lymphocytic leukemia |
small | lymph node (???) | proliferation centres | CD5+, CD23+, CD43+, cyclin D1- | trisomy 12; deletions of 11q, 13q, 17p[6] |
References
- ↑ 1.0 1.1 1.2 1.3 Template:Ref Lester
- ↑ URL: http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html. Accessed on: 10 August 2010.
- ↑ Template:Ref PCPBoD8
- ↑ Template:Ref PCPBoD8
- ↑ URL: http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022&rendertype=table&id=A34029. Accessed on: 20 August 2010.
- ↑ Template:Ref PCPBoD8
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