Thoracic aortic aneurysm causes
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Thoracic aortic aneurysm Microchapters |
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Differentiating Thoracic Aortic Aneurysm from other Diseases |
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Thoracic aortic aneurysm causes On the Web |
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Risk calculators and risk factors for Thoracic aortic aneurysm causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aarti Narayan, M.B.B.S [2]
Overview
Two of the most common causes of thoracic aorta aneurysm are Marfan's syndrome and atherosclerosis. In some centers, a prior history of dissection with aneurysmal dilation is the most common cause of surgical repair.
Causes
Life Threatening Causes
Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.
Common Causes
Causes by Organ System
| Cardiovascular | Atherosclerosis, aortic dissection, bacterial endocarditis, bicuspid aortic valve, systemic hypertension |
| Chemical / poisoning | No underlying causes |
| Dermatologic | No underlying causes |
| Drug Side Effect | No underlying causes |
| Ear Nose Throat | No underlying causes |
| Endocrine | No underlying causes |
| Environmental | No underlying causes |
| Gastroenterologic | No underlying causes |
| Genetic | Marfan syndrome, Ehlers-Danlos syndrome, familial thoracic aortic aneurysms and dissections, bicuspid aortic valve, Loeys-Dietz syndrome, Turner syndrome |
| Hematologic | No underlying causes |
| Iatrogenic | Previous surgery on the aorta |
| Infectious Disease | Syphilis |
| Musculoskeletal / Ortho | No underlying causes |
| Neurologic | No underlying causes |
| Nutritional / Metabolic | No underlying causes |
| Obstetric/Gynecologic | No underlying causes |
| Oncologic | No underlying causes |
| Opthalmologic | No underlying causes |
| Overdose / Toxicity | No underlying causes |
| Psychiatric | No underlying causes |
| Pulmonary | No underlying causes |
| Renal / Electrolyte | No underlying causes |
| Rheum / Immune / Allergy | Ankylosing spondylitis, Behcet's disease, giant cell arteritis, Takayasu's arteritis |
| Sexual | No underlying causes |
| Trauma | Sudden deceleration |
| Urologic | No underlying causes |
| Miscellaneous | No underlying causes |
Causes in Alphabetical Order
- Ankylosing spondylitis
- Aortic dissection
- Aortic stenosis
- Aortitis
- Aortic valve replacement
- Arterial tortuosity syndrome
- Atherosclerosis
- Bacterial infection, often following valvular endocarditis
- Behcet's disease
- Bicuspid aortic valve
- Ehlers-Danlos syndrome
- Familial thoracic aortic aneurysms and dissections
- Giant cell arteritis
- Loeys-Dietz syndrome
- Marfan's syndrome
- Quaternary syphilis
- Reactive arthritis
- Rheumatoid arthritis
- Rheumatoid vasculitis
- Septic embolism
- Takayasu's arteritis
- Temporal arteritis
- Traumatic - Sudden deceleration
- Turner's syndrome
- Wegener's granulomatosis
Causes Based Upon Inherited versus Sporadic versus Syndromic Basis
Sporadic Causes
- Ankylosing spondylitis
- Atherosclerosis
- Bacterial infection, often following valvular endocarditis
- Behcet's disease
- Giant cell arteritis
- Previous injury to the aorta such as an aortic dissection
- Syphilis
- Takayasu's arteritis
- Traumatic - sudden deceleration
Familial Causes
- Familial thoracic aortic aneurysms and dissections
- Bicuspid aortic valve with post-stenotic dilation due to turbulence
Syndromic Causes
- Marfan's syndrome: Aortic root dilation with or without associated aortic regurgitation occurs in 75%-80% of marfan's patients.
- Loeys-Dietz syndrome
- Ehlers-Danlos syndrome
- Turner's syndrome