Thrombophilia causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Causes

Inherited

In a cohort study. the population attributable risk of venous thromboembolism was:[1]

Common types:

Rare forms:

Acquired

Causes of Thrombophilia by Organ System

Cardiovascular Cerebral vein thrombosisAcute myocardial infarctionDeep vein thrombophlebitisPortal vein thrombosisPelvic thrombophlebitis
Drug Side Effect Asparaginasebevacizumabcombined oral contraceptive pillcertolizumab pegolCcproteronediethylstilboestroldrospirenoneeltrombopagerythropoietinethinylestradiolfosfestrolgranulocyte-macrophage colony stimulating factorheparinhormone replacement therapylenalidomidepeginesatidepolyestradiolraloxifenestrontium ranelatetamoxifentobacco smokingtranexamic acidvorinostat
Endocrine Hyperosmolar non-ketotic diabetic coma
Gastroenterologic • Acute pancreatitisPortal hypertension
Genetic Congenital DysfibrinogenemiaFactor II mutationHereditary thrombophlebitisAntithrombin III deficiencyFactor V Leiden mutationProtein C deficiencyProtein S deficiencyKlippel-Trenaunay syndromeKlinefelter syndromeSickle cell diseaseCarbohydrate-deficient glycoprotein syndrome type 1bFactor XII deficiencyHaemoglobin SC diseaseHyperprothrombinemia 20210G-APlasminogen deficiencyActivated protein C resistanceCD59 antigen deficiencyCystathionine beta-synthase deficiency
Hematologic Polycythemia veraEssential thrombocythemiaMyeloproliferative diseaseHyperviscosity syndrome • Paroxysmal Nocturnal HemoglobinuriaThrombocytosis • Raised homocysteine levels
Iatrogenic • Surgical complication
Infectious Disease Intraperitoneal abscessAcute peritonitisVisceral abscessDiverticulitisIntravenous catheter infection
Musculoskeletal / Ortho • Orthopedic surgeries • Abdominal surgery
Nutritional / Metabolic CystathionuriaHomocystinuriaMethyltetrahydrofolate reductase deficiencyMetabolic SyndromeInsulin resistanceFolic acid deficiencyObesity
Obstetric/Gynecologic PregnancyPuerperium periodOvarian hyperstimulation syndrome
Oncologic MalignancyPeritoneal metastasisAdenocarcinoma of cecumAdenocarcinoma of colon • Occult malignancy • LeukemiaPancreatic cancerGlucagonoma
Renal / Electrolyte Chronic renal failureParoxysmal Nocturnal HemoglobinuriaNephrotic syndrome
Rheum / Immune / Allergy Antiphospholipid SyndromeCirculating anticoagulantHeparin induced thrombocytopeniaInflammatory bowel diseaseCrohn's diseaseBehcet diseaseHughes-Stovin syndromePolyarteritis NodosaSLE
Trauma TraumaAbdominal trauma
Miscellaneous Paraneoplastic syndromeHypereosinophilic syndromeImmobility

References

  1. Sode BF, Allin KH, Dahl M, Gyntelberg F, Nordestgaard BG (2013). "Risk of venous thromboembolism and myocardial infarction associated with factor V Leiden and prothrombin mutations and blood type". CMAJ. 185 (5): E229–37. doi:10.1503/cmaj.121636. PMC 3602271. PMID 23382263.

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