Cancer of unknown primary origin historical perspective
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Differentiating Cancer of Unknown Primary Origin from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: ; Roukoz A. Karam, M.D.[2]
Overview
Cancer of unknown primary origin was first discovered in the 1980s and was based solely on imaging studies.
Historical Perspective
Discovery
- Cancer of unknown primary origin was discovered in the 1980s.
- In the beginning, cancer of unknown primary was defined based on imaging results and only few empirical therapy options were available.[1]
Landmark Events in the Development of Treatment Strategies
- Between 1980 and 1990, the definition of cancer of unknown primary origin was based solely on imaging and treatment was limited to few empirical therapies.
- From 1990 to 2000, improvement in imaging techniques and immunohistochemical testing aided in the diagnosis of CUP. This time range also saw the rise of empirical therapy in treating CUP.
- In 2000, the emergence of tissue-of-origin molecular profiling, provided a more successful site-directed therapy especially when used with immunochemical testing. Hence, the years 2000-2010 saw an increase in tailored therapy models.[2]
References
- ↑ Varadhachary GR, Raber MN (2014). "Cancer of unknown primary site". N Engl J Med. 371 (8): 757–65. doi:10.1056/NEJMra1303917. PMID 25140961.
- ↑ Greco FA, Spigel DR, Yardley DA, Erlander MG, Ma XJ, Hainsworth JD (2010). "Molecular profiling in unknown primary cancer: accuracy of tissue of origin prediction". Oncologist. 15 (5): 500–6. doi:10.1634/theoncologist.2009-0328. PMC 3227979. PMID 20427384.