Cancer of unknown primary origin physical examination

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: ; Roukoz A. Karam, M.D.[2]

Overview

There are no remarkable findings in the physical examination of CUP patients; the presentation is variable and depends on many factors including the primary tumor's origin and extent of organs involved.

Physical Examination

• There are no remarkable findings in the physical examination of CUP patients; the presentation is variable and depends on many factors including the primary tumor's origin and extent of organs involved.
• Usually patients with cancer of unknown origin present with involvement of multiple sites of metastases including bone, lung, liver, and lymph nodes.
• Physicians must conduct exhaustive physical examinations including head and neck, skin, genitourinary, breast, and rectal examinations.

Appearance of the Patient

• Patients with cancer of unknown primary origin usually appear cachexic.