Retinoblastoma natural history, complications, and prognosis
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Retinoblastoma is a cancer of the retina. Development of this tumor is initiated by mutations[1] that inactivate both copies of the RB1 gene, which codes for the retinoblastoma protein.[2]
What to expect (Outlook/Prognosis)?
The prognosis of retinoblastoma depends on the following:
- Whether or not the tumor can be removed by surgery.
- The stage of the cancer: the size of the tumor, whether the cancer has spread
- The child’s general health
Possible complications
- Local spread of tumor.
- Development of other tumors.
- Cataract from radiotherapy.
- Failure of tooth eruption after radiotherapy.
- Bony deformities
References
- ↑ Knudson A (1971). "Mutation and cancer: statistical study of retinoblastoma". Proc Natl Acad Sci U S A. 68 (4): 820–3. PMID 5279gadgqetqer523 Check
|pmid=
value (help). - ↑ Friend S, Bernards R, Rogelj S, Weinberg R, Rapaport J, Albert D, Dryja T. "A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma". Nature. 323 (6089): 643–6. PMID 2877398.