Chromosome 9 open reading frame 152 is a protein that in humans is encoded by the C9orf152 gene.[1][2] The exact function of the protein is not completely understood.
The DNA sequence encoding C9orf152 contains a single intron.[3] The final mRNA consists of 2698 base pairs. Nucleotides 66-68 encode an upstream in frame stop codon.[1]
There are three regions predicted to form alpha helices on the final protein.[14][15]
Expression
File:C9orf152 Brain Expression.jpgExpression of C9orf152 in the brain of a mouse via Allen Brain Atlas. The only area of high expression is the dark purple on the left, which is located in the olfactory bulb.
A wide variety of transcription factors interact with the promoter of C9orf152, most notably two olfactory related factors (specifically, a neuron-specific olfactory factor and an olfactory associated zinc finger protein) and a negative glucocorticoid response element.[19]
↑Hedges SB, Dudley J, Kumar S (Dec 2006). "TimeTree: a public knowledge-base of divergence times among organisms". Bioinformatics. 22 (23): 2971–2. doi:10.1093/bioinformatics/btl505. PMID17021158.
↑Ren J, Gao X, Jin C, Zhu M, Wang X, Shaw A, Wen L, Yao X, Xue Y (Jun 2009). "Systematic study of protein sumoylation: Development of a site-specific predictor of SUMOsp 2.0". Proteomics. 9 (12): 3409–3412. doi:10.1002/pmic.200800646. PMID19504496.