Burkitt's lymphoma staging

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

According to the Murphy staging system, there are four stages of Burkitt's lymphoma based on the number of nodes and extra nodal involvement.

Staging

According to the Murphy staging system, there are four stages of Burkitt's lymphoma based on the number of nodes and extra nodal involvement. Staging for Burkitt's lymphoma is provided in the following table:

Murphy staging system
Stage Involvement
Stage I Single nodal or extra nodal site excluding mediastinum or abdomen
Stage II
  • Single extra nodal tumor with regional nodal involvement
  • Two extra nodal tumors on one side of diaphragm
  • Primary gastrointestinal tumor with or without associated mesenteric nodes
  • Two or more nodal areas on one side of diaphragm
Stage IIR Completely resected intra-abdominal disease
Stage III
  • Two single extra nodal tumors on opposite sides of diaphragm
  • All primary intra thoracic tumors
  • All paraspinal or epidural tumors
  • All extensive primary intra-abdominal disease
  • Two or more nodal areas on opposite sides of diaphragm
Stage IIIA Localized, non-resectable abdominal disease
Stage IIIB Widespread multi organ abdominal disease
Stage IV Initial CNS or bone marrow involvement (< 25%)

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