Burkitt's lymphoma natural history, complications and prognosis
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Burkitt's lymphoma Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2], Kamal Akbar, M.D.[3]
Overview
The prognosis varies with the age, children have the most favorable prognosis. Burkitt's lymphoma in children is associated with a 5 year survival rate of 90%. The presence of metastasis in bone marrow or CNS is associated with a particularly poor prognosis among patients with Burkitt's lymphoma.
Complications
Common complications of Burkitt's lymphoma include:
- Disruption of teeth[1]
- Partial obstruction of airway[2]
- Ulceration and drainage[3]
- Tumor lysis syndrome[4]
Prognosis
- In children, prognosis is good with survival rates >90%[5]
- In adults, prognosis is poor, with a 5-year survival rate of 50% and is even worse with bone marrow or CNS involvement (>30% 5-year survival rate).
References
- ↑ Comfort AO (2004). "Burkitt's lymphoma of the jaws: role of dental practitioner in management". Pac Health Dialog. 11 (1): 89–93. PMID 18181448.
- ↑ Aslan G (2013). "Unusual presentation of sporadic Burkitt's lymphoma originating from the nasal septum: a case report". J Med Case Rep. 7: 60. doi:10.1186/1752-1947-7-60. PMC 3599746. PMID 23497670.
- ↑ Madabhavi I, Patel A, Revannasiddaiah S, Choudhary M, Anand A, Das P; et al. (2014). "Primary esophageal Burkitt's lymphoma: a rare case report and review of literature". Gastroenterol Hepatol Bed Bench. 7 (4): 230–7. PMC 4185878. PMID 25289138.
- ↑ Wössmann W, Schrappe M, Meyer U, Zimmermann M, Reiter A (2003). "Incidence of tumor lysis syndrome in children with advanced stage Burkitt's lymphoma/leukemia before and after introduction of prophylactic use of urate oxidase". Ann Hematol. 82 (3): 160–5. doi:10.1007/s00277-003-0608-2. PMID 12634948.
- ↑ Jacobson C, LaCasce A (2014). "How I treat Burkitt lymphoma in adults". Blood. 124 (19): 2913–20. doi:10.1182/blood-2014-06-538504. PMID 25258344.