Burkitt's lymphoma diagnostic study of choice

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Burkitt's lymphoma Microchapters


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Differentiating Burkitt's lymphoma from other Diseases

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Diagnostic Study Of Choice


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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: , Kamal Akbar, M.D.[2]


In Burkitts lymphoma tissue biopsy remains the preferred diagnostic study of choice. The biopsy will yield confirmatory results when histopathological and immunohistochemical techniques are used.

Diagnostic Study of Choice

Biopsy of the affected lymph nodes remains to be the diagnostic study of choice which confirms Burkitts lymphoma.

Study of choice

  • Lymph node or extra nodal tissue biopsy is diagnostic of Burkitt's lymphoma.
  • To view the characteristic findings of Burkitt's lymphoma biopsy please click here.


According to the Murphy staging system, there are four stages of Burkitt's lymphoma based on the number of nodes involved and the extra nodal spread.

Staging for Burkitt's lymphoma is provided in the following table:[1]

Murphy staging system
Stage Features
Stage I
Stage II
Stage IIR
  • Completely resected intra-abdominal disease
Stage III
Stage IIIA
Stage IIIB
Stage IV
Diagnostic results

The following finding(s) on performing biopsy and FISH are confirmatory for Burkitts lymphoma :


  1. Perkins AS, Friedberg JW (2008). "Burkitt lymphoma in adults". Hematology Am Soc Hematol Educ Program: 341–8. doi:10.1182/asheducation-2008.1.341. PMID 19074108.
  2. 2.0 2.1 2.2 Sandlund JT (2012). "Burkitt lymphoma: staging and response evaluation". Br J Haematol. 156 (6): 761–5. doi:10.1111/j.1365-2141.2012.09026.x. PMC 3292702. PMID 22296338.
  3. Aquino G, Marra L, Cantile M, De Chiara A, Liguori G, Curcio MP; et al. (2013). "MYC chromosomal aberration in differential diagnosis between Burkitt and other aggressive lymphomas". Infect Agent Cancer. 8 (1): 37. doi:10.1186/1750-9378-8-37. PMC 3850004. PMID 24079473.
  4. Andrade-Filho Jde S (2014). "Analogies in medicine: starry-sky appearance". Rev Inst Med Trop Sao Paulo. 56 (6): 541–2. PMC 4296877. PMID 25351551.

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