Cefazolin sodium: Difference between revisions

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==Mechanism of Action==
==Mechanism of Action==


Cefazolin sodium belongs to the first-genaration [[Cephalosporins]].[[Cephalosporins]] are bactericidal and have the same mode of action as other beta-lactam antibiotics (such as [[penicillins]]). [[Cephalosporins]] disrupt the synthesis of the [[peptidoglycan ]]layer of bacterial cell walls. The [[peptidoglycan ]]layer is important for cell wall structural integrity, especially in Gram-positive organisms. The final transpeptidation step in the synthesis of the [[peptidoglycan ]]is facilitated by transpeptidases known as [[penicillins]] binding proteins (PBPs)
Cefazolin sodium belongs to the first-genaration [[Cephalosporins]].[[Cephalosporins]] are bactericidal and have the same mode of action as other beta-lactam antibiotics (such as [[penicillins]]). [[Cephalosporins]] disrupt the synthesis of the [[peptidoglycan]] layer of bacterial cell walls. The [[peptidoglycan]] layer is important for cell wall structural integrity, especially in Gram-positive organisms. The final transpeptidation step in the synthesis of the [[peptidoglycan]] is facilitated by transpeptidases known as [[penicillin-binding protein]]s (PBPs).


==References==
==References==

Revision as of 00:25, 6 January 2014

Cefazolin Sodium
CEFAZOLIN® FDA Package Insert
Description
Clinical Pharmacology
Microbiology
Indications and Usage
Contraindications
Warnings and Precautions
Adverse Reactions
Dosage and Administration
Compatibility, Reconstitution, and Stability
How Supplied
Labels and Packages

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sheng Shi, M.D. [2]

Overview

Cefazolin (INN), also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic.

The drug is usually administrated either by intramuscular injection (injection into a large muscle) or intravenous infusion (intravenous fluid into a vein).

Category

Cephalosporin, First-Generation

US Brand Names

ANCEF®

FDA Package Insert

Description | Clinical Pharmacology | Microbiology | Indications and Usage | Contraindications | Warnings and Precautions | Adverse Reactions | Dosage and Administration | Compatibility, Reconstitution, and Stability | How Supplied | Labels and Packages

Mechanism of Action

Cefazolin sodium belongs to the first-genaration Cephalosporins.Cephalosporins are bactericidal and have the same mode of action as other beta-lactam antibiotics (such as penicillins). Cephalosporins disrupt the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The final transpeptidation step in the synthesis of the peptidoglycan is facilitated by transpeptidases known as penicillin-binding proteins (PBPs).

References