Cefaclor: Difference between revisions
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==Mechanisms of Action== | ==Mechanisms of Action== | ||
Cephalosporins disrupt the synthesis of the [[peptidoglycan]] layer of bacterial [[cell wall]]s. The peptidoglycan layer is important for cell wall structural integrity, especially in [[Gram-positive]] organisms. The final transpeptidation step in the synthesis of the peptidoglycan is facilitated by [[transpeptidase]]s known as [[penicillin binding protein]]s (PBPs). | |||
==References== | ==References== | ||
Revision as of 16:50, 24 December 2013
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Cefaclor, also known as cefachlor or cefaclorum (brand names Ceclor, Distaclor, Keflor, Raniclor), is a second-generation cephalosporin antibiotic used to treat certain infections caused by bacteria such as pneumonia and ear, lung, skin, throat, and urinary tract infections.
Category
Cephalosporin,Second-Generation
US Brand Names
Ceclor®
FDA Package Insert
Description | Clinical Pharmacology | Microbiology | Indications and Usage | Contraindications | Warnings and Precautions | Adverse Reactions | Overdosage | Clinical Studies | Dosage and Administration | How Supplied | Labels and Packages
Mechanisms of Action
Cephalosporins disrupt the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The final transpeptidation step in the synthesis of the peptidoglycan is facilitated by transpeptidases known as penicillin binding proteins (PBPs).