Cefepime microbiology: Difference between revisions
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==Microbiology== | |||
Cefepime is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. | Cefepime is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. | ||
Cefepime has a broad spectrum of in vitro activity that encompasses a wide range of | Cefepime has a broad spectrum of in vitro activity that encompasses a wide range of | ||
| Line 6: | Line 7: | ||
Within bacterial cells, the molecular targets of cefepime are the penicillin binding | Within bacterial cells, the molecular targets of cefepime are the penicillin binding | ||
proteins (PBP). | proteins (PBP). | ||
==Susceptible organisms== | |||
'''Aerobic Gram-Negative Microorganisms:''' | '''Aerobic Gram-Negative Microorganisms:''' | ||
Enterobacter | *[[Enterobacter]] | ||
Escherichia coli | *[[Escherichia coli]] | ||
Klebsiella pneumoniae | *[[Klebsiella pneumoniae]] | ||
Proteus mirabilis | *[[Proteus mirabilis]] | ||
Pseudomonas aeruginosa | *[[Pseudomonas aeruginosa]] | ||
'''Aerobic Gram-Positive Microorganisms:''' | '''Aerobic Gram-Positive Microorganisms:''' | ||
Staphylococcus aureus (methicillin-susceptible isolates only) | *[[Staphylococcus aureus]] (methicillin-susceptible isolates only) | ||
Streptococcus pneumoniae | *[[Streptococcus pneumoniae]] | ||
Streptococcus pyogenes (Lancefield’s Group A streptococci) | *[[Streptococcus pyogenes]] (Lancefield’s Group A streptococci) | ||
Viridans group streptococci. | *[[Viridans group streptococci]]. | ||
Revision as of 15:52, 18 December 2013
Microbiology
Cefepime is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. Cefepime has a broad spectrum of in vitro activity that encompasses a wide range of Gram-positive and Gram-negative bacteria. Cefepime has a low affinity for chromosomally-encoded beta-lactamases. Cefepime is highly resistant to hydrolysis by most beta-lactamases and exhibits rapid penetration into Gram-negative bacterial cells. Within bacterial cells, the molecular targets of cefepime are the penicillin binding proteins (PBP).
Susceptible organisms
Aerobic Gram-Negative Microorganisms:
Aerobic Gram-Positive Microorganisms:
- Staphylococcus aureus (methicillin-susceptible isolates only)
- Streptococcus pneumoniae
- Streptococcus pyogenes (Lancefield’s Group A streptococci)
- Viridans group streptococci.