Coccidioidomycosis medical therapy: Difference between revisions
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==Treatment== | ==Treatment== | ||
The drug therapy is guided by the severity of symptoms and the immune status of the patient. Since most patients are asymptomatic or mildly affected, no treatment or a single drug Azole therapy (fluconazole or itraconazole) may be sufficient in these cases.However patients with HIV, immune-compromised, those on steroids or pregnant females need | The drug therapy is guided by the severity of symptoms and the immune status of the patient. Since most patients are asymptomatic or mildly affected, no treatment or a single drug Azole therapy (fluconazole or itraconazole) may be sufficient in these cases.However patients with HIV, immune-compromised, those on steroids or pregnant females need much more aggressive approach.More recently resistant cases are being treated with voriconazole or posaconazole.<ref name="Chen-2011">{{Cite journal | last1 = Chen | first1 = S. | last2 = Erhart | first2 = LM. | last3 = Anderson | first3 = S. | last4 = Komatsu | first4 = K. | last5 = Park | first5 = B. | last6 = Chiller | first6 = T. | last7 = Sunenshine | first7 = R. | title = Coccidioidomycosis: knowledge, attitudes, and practices among healthcare providers--Arizona, 2007. | journal = Med Mycol | volume = 49 | issue = 6 | pages = 649-56 | month = Aug | year = 2011 | doi = 10.3109/13693786.2010.547995 | PMID = 21247229 }}</ref>. More severe cases may require intravenous Amphotericin B, with or without simultaneous oral azole therapy. Pregnant females are treated by Intravenous amphotericin B only. | ||
Severe cases like meningitis or vasculitis | Severe cases like meningitis or vasculitis often need initial in-patient treatment with oral azoles plus intravenous amphotericin B with or without intrathecal amphotericin B. Untreated cases may sometimes be fatal. | ||
Revision as of 20:36, 19 November 2013
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Coccidioidomycosis Microchapters |
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Coccidioidomycosis medical therapy On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: ; Vidit Bhargava, M.B.B.S [2]
Treatment
The drug therapy is guided by the severity of symptoms and the immune status of the patient. Since most patients are asymptomatic or mildly affected, no treatment or a single drug Azole therapy (fluconazole or itraconazole) may be sufficient in these cases.However patients with HIV, immune-compromised, those on steroids or pregnant females need much more aggressive approach.More recently resistant cases are being treated with voriconazole or posaconazole.[1]. More severe cases may require intravenous Amphotericin B, with or without simultaneous oral azole therapy. Pregnant females are treated by Intravenous amphotericin B only.
Severe cases like meningitis or vasculitis often need initial in-patient treatment with oral azoles plus intravenous amphotericin B with or without intrathecal amphotericin B. Untreated cases may sometimes be fatal.
References
- ↑ Chen, S.; Erhart, LM.; Anderson, S.; Komatsu, K.; Park, B.; Chiller, T.; Sunenshine, R. (2011). "Coccidioidomycosis: knowledge, attitudes, and practices among healthcare providers--Arizona, 2007". Med Mycol. 49 (6): 649–56. doi:10.3109/13693786.2010.547995. PMID 21247229. Unknown parameter
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