Wide complex tachycardia medical therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Medical Therapy

Wide complex tachycardia QRS ≥ 120ms

Do the following simultaneously: - Assess and support ABC's as needed - Give oxygen - Monitor ECG, BP, oxymetry - Identify and treat reversible causes

Is the patient stable? Unstable signs include: - Chest pain - Congestive heart failure - Hypotension - Loss of consciousness - Seizures

Yes

No

Is the rhythm regular?

Immediate synchronized cardioversion -Establish IV access - Give IV sedation if the patient is conscious - Consider expert consultation

Regular rhythm

Irregular rhythm

Ventricular tachycardia or uncertain rhythm? - Amiodarone 150 mg IV over 10 min Repeat as needed for a maximal dose of 2.2g/24h - Prepare for elective synchronized cardioversion

SVT with aberrancy? - Adenosise 6 mg rapid IV push - If no conversion give 12 mg IV push - May repeat 12 mg dose once

Afib with aberrancy? - Consider expert consultation - Control rate e.g diltiazem or beta blockers Use beta blockers with caution in pulmonary diseases or CHF

Pre-excited Afib (Afib + WPW) - Consider expert consultation - Avoid AV nodal blocking agents e.g adenosine, digoxin, diltiazem and verapamil - Consider amiodarone 150 mg IV over 10 min

Recurrent polymorphic VT? Consider expert consultation

Torsades de pointes? Magnesium Load with 1-2 g over 5-60 min, then infusion

• If stable: (More patients than you think)
• Do not use Ca²⁺ channel blocker, digoxin or adenosine if you don't not know the etiology of the wide complex tachycardia. Ca²⁺ channel blockers and digoxin can lead to accelerated conduction down a bypass tract and VF.
• Though ACLS guidelines recommend a diagnostic trial of adenosine, it can precipitate VF in some patients with SVT. Patients who have underlying coronary disease may become ischemic from coronary steal. Rhythm can degenerate and lead to VF that cannot be resuscitated. Furthermore, some VT (specially those with structurally normal hearts) are adenosine responsive and can terminate.

  1. Etiology uncertain

     • Pronestyl 15 mg/kg load over 30 minutes then 2-6 mg/min gtt

  2. Ventricular tachycardia with active ischemia

     • Lidocaine 1 mg/kg q5-10 min up to 3 times then 2-6 mg/min gtt
     • If unsuccessful, pronestyl as above
     • If unsuccessful, IV amiodarone 150-300 load over 15-20 min. 30-60 mg/hr gtt for total of 1 gram

  3. Ventricular tachycardia in setting of cardiomyopathy

     • Skip lidocaine and go straight to pronestyl

  4. Positively SVT with aberrancy

     • Adenosine 6 mg rapid IV bolus in large vein. May repeat with 12 mg x2.
     • Lopressor 2.5-5.0 mg IV
     • Diltiazem 10-20 mg bolus followed by gtt 5-20 mg/hr
     • Verapamil 2.5-5.0 mg bolus.
     • Avoid digoxin. Takes too long to work and can be proarrhythmic
     • Pronestyl as above

  5. Antidromic AVRT

     • If 100% positive AF is not underlying, can terminate with a nodal blocker
     • If unsure, pronestyl as above

Defibrillation

Indications for defibrillation include the following:

• Chest pain
• Congestive heart failure (CHF)
• Hypotension with symptoms
• Loss of consciousness
• Seizure