Squamous cell carcinoma of the skin other diagnostic studies: Difference between revisions
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{{CMG}}; '''Associate Editor(s)-in-Chief:''' [[User:Aditya Govindavarjhulla|Aditya Govindavarjhulla, M.B.B.S.]] [mailto:agovi@perfuse.org], [[User:Raviteja Reddy Guddeti|Raviteja Guddeti, M.B.B.S.]] [mailto:rgudetti@perfuse.org] | |||
== Other Diagnostic Studies == | == Other Diagnostic Studies == | ||
There are few other modalities used for diagnosis and follow up. | There are few other modalities used for diagnosis and follow up. | ||
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* Few cells may express Involucrin on their surface which may help in diagnosis at times and differentiating from other kinds of tumors.<ref name="pmid7690007">{{cite journal |author=Suo Z, Holm R, Nesland JM |title=Squamous cell carcinomas. An immunohistochemical study of cytokeratins and involucrin in primary and metastatic tumours |journal=Histopathology |volume=23 |issue=1 |pages=45–54 |year=1993 |month=July |pmid=7690007 |doi= |url=}}</ref> | * Few cells may express Involucrin on their surface which may help in diagnosis at times and differentiating from other kinds of tumors.<ref name="pmid7690007">{{cite journal |author=Suo Z, Holm R, Nesland JM |title=Squamous cell carcinomas. An immunohistochemical study of cytokeratins and involucrin in primary and metastatic tumours |journal=Histopathology |volume=23 |issue=1 |pages=45–54 |year=1993 |month=July |pmid=7690007 |doi= |url=}}</ref> | ||
* There is an extracellular protein called Laminin, which can be used for understanding tumor differentiation, invasion and prognostic indicator.<ref name="pmid22665747">{{cite journal |author=Koshy AV, Rao NN, Kamat SS, Kiswani K, Kapse SC, Shaikh NA |title=Expression of extracellular matrix-laminin in oral squamous cell carcinoma: an immunohistochemical study |journal=J Contemp Dent Pract |volume=13 |issue=2 |pages=194–200 |year=2012 |pmid=22665747 |doi= |url=}}</ref> | * There is an extracellular protein called Laminin, which can be used for understanding tumor differentiation, invasion and prognostic indicator.<ref name="pmid22665747">{{cite journal |author=Koshy AV, Rao NN, Kamat SS, Kiswani K, Kapse SC, Shaikh NA |title=Expression of extracellular matrix-laminin in oral squamous cell carcinoma: an immunohistochemical study |journal=J Contemp Dent Pract |volume=13 |issue=2 |pages=194–200 |year=2012 |pmid=22665747 |doi= |url=}}</ref> | ||
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Revision as of 20:55, 15 June 2012
Squamous cell carcinoma of the skin Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aditya Govindavarjhulla, M.B.B.S. [2], Raviteja Guddeti, M.B.B.S. [3]
Other Diagnostic Studies
There are few other modalities used for diagnosis and follow up.
FTIR
- Fourier Transform Infrared Imaging(FTIR) is a modern analytic technique, which uses infrared rays to evaluate for the histology of the tissue & necessary for diagnosis at early stage.[4]
- It is a non invasive technique.
- It can be used in intra operative and surgical specimen analysis.
Immunohistochemistry
- There will be certain proteins/markers on the cell surface or in the matrix. Evaluation of them is useful in diagnosis and determining the prognosis.
- Expression of certain Cytokeratins(CK)by tumor cells is helpful in determining the metastatic ability.
- Few cells may express Involucrin on their surface which may help in diagnosis at times and differentiating from other kinds of tumors.[1]
- There is an extracellular protein called Laminin, which can be used for understanding tumor differentiation, invasion and prognostic indicator.[2]
- ↑ Suo Z, Holm R, Nesland JM (1993). "Squamous cell carcinomas. An immunohistochemical study of cytokeratins and involucrin in primary and metastatic tumours". Histopathology. 23 (1): 45–54. PMID 7690007. Unknown parameter
|month=
ignored (help) - ↑ Koshy AV, Rao NN, Kamat SS, Kiswani K, Kapse SC, Shaikh NA (2012). "Expression of extracellular matrix-laminin in oral squamous cell carcinoma: an immunohistochemical study". J Contemp Dent Pract. 13 (2): 194–200. PMID 22665747.