Eczema causes: Difference between revisions

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==Causes==
==Causes==
*Damage from the [[Enzyme|enzymatic]] activity of [[allergens]] is usually prevented by the body's own [[protease inhibitor]]s, such as, ''[[LEKTI]]'',  produced from the gene ''[[SPINK5]]''.  
*Damage from the [[Enzyme|enzymatic]] activity of [[allergens]] is usually prevented by the body's own [[protease inhibitor]]s, such as, ''[[LEKTI]]'',  produced from the gene ''[[SPINK5]]''.  
**[[Netherton’s syndrome]], a [[congenital]] condition presenting with [[erythroderma]], [[food allergy]], [[hay fever]], [[asthma]], and [[urticaria]], results from the [[mutation]] of this [[gene]]. <ref name="pmid11544479">{{cite journal |author=Walley AJ, Chavanas S, Moffatt MF, ''et al'' |title=Gene polymorphism in Netherton and common atopic disease |journal=Nat. Genet. |volume=29 |issue=2 |pages=175–8 |year=2001[[Mutations]] in this gene are known to cause  |pmid=11544479 |doi=10.1038/ng728}}</ref>
*Lack of [[filaggrin]] [[gene]] causes [[dry skin]] and impaired [[skin]] [[barrier]] [[function]]. <ref name=filaggrin>Palmer, C.N. ''et al.'' (2006) Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. ''Nature Genetics''  '''38'''(4), 441-6. PMID 16550169</ref>
*Lack of [[filaggrin]] [[gene]] causes [[dry skin]] and impaired [[skin]] [[barrier]] [[function]]. <ref name=filaggrin>Palmer, C.N. ''et al.'' (2006) Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. ''Nature Genetics''  '''38'''(4), 441-6. PMID 16550169</ref>



Revision as of 01:44, 26 May 2022

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Edzel Lorraine Co, D.M.D., M.D.

Overview

Eczema could be due to a genetic problem, or a result of the adverse effect of certain medication.

Causes

Common Medications with Eczema as the Adverse Drug Effect


Table 1. More Common types of Eczema.
Medication
Cidofovir
Flurbiprofen
Olaparib
Siltuximab
Sorafenib
Tiagabine

References

  1. Palmer, C.N. et al. (2006) Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nature Genetics 38(4), 441-6. PMID 16550169