Sjögren's syndrome natural history, complications and prognosis: Difference between revisions
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==Natural History== | ==Natural History== | ||
===Natural History=== | ===Natural History=== | ||
*The symptoms of | *The symptoms of Sjögren's syndrome usually develop in the 4th and 5th decade of life, and start with symptoms such as ocular and oral dryness.<ref name="pmid11920410">{{cite journal |vauthors=Ioannidis JP, Vassiliou VA, Moutsopoulos HM |title=Long-term risk of mortality and lymphoproliferative disease and predictive classification of primary Sjögren's syndrome |journal=Arthritis Rheum. |volume=46 |issue=3 |pages=741–7 |date=March 2002 |pmid=11920410 |doi=10.1002/art.10221 |url=}}</ref> | ||
*If left untreated, 4.3% of patients with Sjögren's syndrome may progress to develop non-Hodgkin lymphoma. | |||
*If left untreated, | |||
===Complications=== | ===Complications=== |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Natural History
Natural History
- The symptoms of Sjögren's syndrome usually develop in the 4th and 5th decade of life, and start with symptoms such as ocular and oral dryness.[1]
- If left untreated, 4.3% of patients with Sjögren's syndrome may progress to develop non-Hodgkin lymphoma.
Complications
- Common complications of Sjögren's syndrome include:
- Dental cavities
- Yeast infections
- Blurred vision and corneal damage
- Pneumonia
- Bronchitis
- Lymphoma
- peripheral neuropathy
- Myelitis
- Optic neuritis
Prognosis
- Prognosis is generally good and presence of low complement level is associated with a particularly poor prognosis among patients with Sjögren's syndrome.[2]
- Primary Sjögren syndrome is associated with lower cardiovascular risk factors complication such as myocardial infraction and stroke.[3]
Complications
Prognosis
References
- ↑ Ioannidis JP, Vassiliou VA, Moutsopoulos HM (March 2002). "Long-term risk of mortality and lymphoproliferative disease and predictive classification of primary Sjögren's syndrome". Arthritis Rheum. 46 (3): 741–7. doi:10.1002/art.10221. PMID 11920410.
- ↑ Ramos-Casals M, Brito-Zerón P, Yagüe J, Akasbi M, Bautista R, Ruano M, Claver G, Gil V, Font J (January 2005). "Hypocomplementaemia as an immunological marker of morbidity and mortality in patients with primary Sjogren's syndrome". Rheumatology (Oxford). 44 (1): 89–94. doi:10.1093/rheumatology/keh407. PMID 15381790.
- ↑ Gupta S, Gupta N (2017). "Sjögren Syndrome and Pregnancy: A Literature Review". Perm J. 21. doi:10.7812/TPP/16-047. PMC 5267941. PMID 28080954.