Hereditary pancreatitis history and symptoms: Difference between revisions
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==History and Symptoms== | ==History and Symptoms== | ||
*The majority of patients with [disease name] are asymptomatic. | *The majority of patients with [disease name] are asymptomatic. | ||
* Presentation depends upon dysfunction in any one of the following: | |||
* | ** [[Biliary tract]] obstruction; presenting as [[jaundice]] | ||
* | ** [[Exocrine]] dysfunction; presenting as [[malabsorption]] | ||
=== | ** [[Endocrine]] dysfunction; presenting as [[diabetes]] | ||
Patients | Patients with chronic pancreatitis usually present with: | ||
*[ | * Persistent [[abdominal pain]] with episodic flares may or may not be associated with food intake<ref name="pmid6706066">{{cite journal |vauthors=Ammann RW, Akovbiantz A, Largiader F, Schueler G |title=Course and outcome of chronic pancreatitis. Longitudinal study of a mixed medical-surgical series of 245 patients |journal=Gastroenterology |volume=86 |issue=5 Pt 1 |pages=820–8 |year=1984 |pmid=6706066 |doi= |url=}}</ref><ref name="pmid7792289">{{cite journal |vauthors=Lankisch PG, Seidensticker F, Löhr-Happe A, Otto J, Creutzfeldt W |title=The course of pain is the same in alcohol- and nonalcohol-induced chronic pancreatitis |journal=Pancreas |volume=10 |issue=4 |pages=338–41 |year=1995 |pmid=7792289 |doi= |url=}}</ref><ref name="pmid6706079">{{cite journal |vauthors=Warshaw AL |title=Pain in chronic pancreatitis. Patients, patience, and the impatient surgeon |journal=Gastroenterology |volume=86 |issue=5 Pt 1 |pages=987–9 |year=1984 |pmid=6706079 |doi= |url=}}</ref><ref name="pmid7926511">{{cite journal |vauthors=Layer P, Yamamoto H, Kalthoff L, Clain JE, Bakken LJ, DiMagno EP |title=The different courses of early- and late-onset idiopathic and alcoholic chronic pancreatitis |journal=Gastroenterology |volume=107 |issue=5 |pages=1481–7 |year=1994 |pmid=7926511 |doi= |url=}}</ref>. Typical features of pain are: | ||
*[ | ** Located in the [[epigastrium]] | ||
*[ | ** Radiating to the back | ||
=== | ** May be associated with nausea and [[Nausea and vomiting|vomiting]] | ||
** Usually worse 15-30min after meal | |||
*[ | ** Initially it occurs in discrete episodes but later on as the disease progresses, it changes to continuous-like pattern | ||
*[ | * [[Steatorrhea]] resulting from [[malabsorption]] of the fats in food (greasy, loose, very bad smelling stools that are difficult to flush away).<ref name="pmid4693931">{{cite journal |vauthors=DiMagno EP, Go VL, Summerskill WH |title=Relations between pancreatic enzyme outputs and malabsorption in severe pancreatic insufficiency |journal=N. Engl. J. Med. |volume=288 |issue=16 |pages=813–5 |year=1973 |pmid=4693931 |doi=10.1056/NEJM197304192881603 |url=}}</ref><ref name="pmid9365465">{{cite journal |vauthors=Mergener K, Baillie J |title=Chronic pancreatitis |journal=Lancet |volume=350 |issue=9088 |pages=1379–85 |year=1997 |pmid=9365465 |doi=10.1016/S0140-6736(97)07332-7 |url=}}</ref><ref name="pmid5547614">{{cite journal |vauthors=Toskes PP, Hansell J, Cerda J, Deren JJ |title=Vitamin B 12 malabsorption in chronic pancreatic insufficiency |journal=N. Engl. J. Med. |volume=284 |issue=12 |pages=627–32 |year=1971 |pmid=5547614 |doi=10.1056/NEJM197103252841202 |url=}}</ref> | ||
*[ | *Pancreatic [[diabetes]]<ref name="pmid4693931">{{cite journal |vauthors=DiMagno EP, Go VL, Summerskill WH |title=Relations between pancreatic enzyme outputs and malabsorption in severe pancreatic insufficiency |journal=N. Engl. J. Med. |volume=288 |issue=16 |pages=813–5 |year=1973 |pmid=4693931 |doi=10.1056/NEJM197304192881603 |url=}}</ref><ref name="pmid11054391">{{cite journal |vauthors=Malka D, Hammel P, Sauvanet A, Rufat P, O'Toole D, Bardet P, Belghiti J, Bernades P, Ruszniewski P, Lévy P |title=Risk factors for diabetes mellitus in chronic pancreatitis |journal=Gastroenterology |volume=119 |issue=5 |pages=1324–32 |year=2000 |pmid=11054391 |doi= |url=}}</ref><ref name="pmid9365465">{{cite journal |vauthors=Mergener K, Baillie J |title=Chronic pancreatitis |journal=Lancet |volume=350 |issue=9088 |pages=1379–85 |year=1997 |pmid=9365465 |doi=10.1016/S0140-6736(97)07332-7 |url=}}</ref> | ||
*[[Nausea]] | |||
* [[Weight loss]] | |||
* [[Pseudocyst]] | |||
* [[Pancreatic cancer]] | |||
===Less Common Symptoms=== | ===Less Common Symptoms=== | ||
Less common symptoms of [disease name] include | Less common symptoms of [disease name] include | ||
*[ | * [[Pseudocyst]] | ||
*[ | * [[Pancreatic cancer]] | ||
==References== | ==References== | ||
Revision as of 00:59, 7 January 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Iqra Qamar M.D.[2]
Overview
The majority of patients with [disease name] are asymptomatic.
OR
The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3]. Common symptoms of [disease] include [symptom 1], [symptom 2], and [symptom 3]. Less common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].
History and Symptoms
- The majority of patients with [disease name] are asymptomatic.
- Presentation depends upon dysfunction in any one of the following:
- Biliary tract obstruction; presenting as jaundice
- Exocrine dysfunction; presenting as malabsorption
- Endocrine dysfunction; presenting as diabetes
Patients with chronic pancreatitis usually present with:
- Persistent abdominal pain with episodic flares may or may not be associated with food intake[1][2][3][4]. Typical features of pain are:
- Located in the epigastrium
- Radiating to the back
- May be associated with nausea and vomiting
- Usually worse 15-30min after meal
- Initially it occurs in discrete episodes but later on as the disease progresses, it changes to continuous-like pattern
- Steatorrhea resulting from malabsorption of the fats in food (greasy, loose, very bad smelling stools that are difficult to flush away).[5][6][7]
- Pancreatic diabetes[5][8][6]
- Nausea
- Weight loss
- Pseudocyst
- Pancreatic cancer
Less Common Symptoms
Less common symptoms of [disease name] include
References
- ↑ Ammann RW, Akovbiantz A, Largiader F, Schueler G (1984). "Course and outcome of chronic pancreatitis. Longitudinal study of a mixed medical-surgical series of 245 patients". Gastroenterology. 86 (5 Pt 1): 820–8. PMID 6706066.
- ↑ Lankisch PG, Seidensticker F, Löhr-Happe A, Otto J, Creutzfeldt W (1995). "The course of pain is the same in alcohol- and nonalcohol-induced chronic pancreatitis". Pancreas. 10 (4): 338–41. PMID 7792289.
- ↑ Warshaw AL (1984). "Pain in chronic pancreatitis. Patients, patience, and the impatient surgeon". Gastroenterology. 86 (5 Pt 1): 987–9. PMID 6706079.
- ↑ Layer P, Yamamoto H, Kalthoff L, Clain JE, Bakken LJ, DiMagno EP (1994). "The different courses of early- and late-onset idiopathic and alcoholic chronic pancreatitis". Gastroenterology. 107 (5): 1481–7. PMID 7926511.
- ↑ 5.0 5.1 DiMagno EP, Go VL, Summerskill WH (1973). "Relations between pancreatic enzyme outputs and malabsorption in severe pancreatic insufficiency". N. Engl. J. Med. 288 (16): 813–5. doi:10.1056/NEJM197304192881603. PMID 4693931.
- ↑ 6.0 6.1 Mergener K, Baillie J (1997). "Chronic pancreatitis". Lancet. 350 (9088): 1379–85. doi:10.1016/S0140-6736(97)07332-7. PMID 9365465.
- ↑ Toskes PP, Hansell J, Cerda J, Deren JJ (1971). "Vitamin B 12 malabsorption in chronic pancreatic insufficiency". N. Engl. J. Med. 284 (12): 627–32. doi:10.1056/NEJM197103252841202. PMID 5547614.
- ↑ Malka D, Hammel P, Sauvanet A, Rufat P, O'Toole D, Bardet P, Belghiti J, Bernades P, Ruszniewski P, Lévy P (2000). "Risk factors for diabetes mellitus in chronic pancreatitis". Gastroenterology. 119 (5): 1324–32. PMID 11054391.