Hereditary pancreatitis risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Iqra Qamar M.D.[2]
Overview
Common risk factors in the development of Hereditary pancreatitis include smoking, alcohol consumption, lack of antioxidants, genetic mutations such as increased PRSS1 gene expression and CTRC gene mutations.
Risk Factors
Common risk factors in the development of Hereditary pancreatitis include smoking, alcohol consumption, lack of antioxidants, genetic mutations such as increased PRSS1 gene expression and CTRC gene mutations.
Common Risk Factors
- Common risk factors in the development of Hereditary pancreatitis may be occupational, environmental, and genetic.
- Common risk factors in the development of Hereditary pancreatitis include:[1][2][3][4]
- Smoking[5]
- Alcohol consumption
- Lack of antioxidants
- Increased PRSS1 gene expression[6]
- CTRC gene mutations[7][8][9][10][11]
References
- ↑ Keim V, Bauer N, Teich N, Simon P, Lerch MM, Mössner J (2001). "Clinical characterization of patients with hereditary pancreatitis and mutations in the cationic trypsinogen gene". Am. J. Med. 111 (8): 622–6. PMID 11755505.
- ↑ Sossenheimer MJ, Aston CE, Preston RA, Gates LK, Ulrich CD, Martin SP, Zhang Y, Gorry MC, Ehrlich GD, Whitcomb DC (1997). "Clinical characteristics of hereditary pancreatitis in a large family, based on high-risk haplotype. The Midwest Multicenter Pancreatic Study Group (MMPSG)". Am. J. Gastroenterol. 92 (7): 1113–6. PMID 9219780.
- ↑ Sibert JR (1978). "Hereditary pancreatitis in England and Wales". J. Med. Genet. 15 (3): 189–201. PMC 1013676. PMID 671483.
- ↑ Amann ST, Gates LK, Aston CE, Pandya A, Whitcomb DC (2001). "Expression and penetrance of the hereditary pancreatitis phenotype in monozygotic twins". Gut. 48 (4): 542–7. PMC 1728254. PMID 11247900.
- ↑ Lowenfels AB, Maisonneuve P, Whitcomb DC, Lerch MM, DiMagno EP (2001). "Cigarette smoking as a risk factor for pancreatic cancer in patients with hereditary pancreatitis". JAMA. 286 (2): 169–70. PMID 11448279.
- ↑ Whitcomb DC, LaRusch J, Krasinskas AM, Klei L, Smith JP, Brand RE, Neoptolemos JP, Lerch MM, Tector M, Sandhu BS, Guda NM, Orlichenko L, Alkaade S, Amann ST, Anderson MA, Baillie J, Banks PA, Conwell D, Coté GA, Cotton PB, DiSario J, Farrer LA, Forsmark CE, Johnstone M, Gardner TB, Gelrud A, Greenhalf W, Haines JL, Hartman DJ, Hawes RA, Lawrence C, Lewis M, Mayerle J, Mayeux R, Melhem NM, Money ME, Muniraj T, Papachristou GI, Pericak-Vance MA, Romagnuolo J, Schellenberg GD, Sherman S, Simon P, Singh VP, Slivka A, Stolz D, Sutton R, Weiss FU, Wilcox CM, Zarnescu NO, Wisniewski SR, O'Connell MR, Kienholz ML, Roeder K, Barmada MM, Yadav D, Devlin B (2012). "Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis". Nat. Genet. 44 (12): 1349–54. doi:10.1038/ng.2466. PMC 3510344. PMID 23143602.
- ↑ Rosendahl J, Landt O, Bernadova J, Kovacs P, Teich N, Bödeker H, Keim V, Ruffert C, Mössner J, Kage A, Stumvoll M, Groneberg D, Krüger R, Luck W, Treiber M, Becker M, Witt H (2013). "CFTR, SPINK1, CTRC and PRSS1 variants in chronic pancreatitis: is the role of mutated CFTR overestimated?". Gut. 62 (4): 582–92. doi:10.1136/gutjnl-2011-300645. PMID 22427236.
- ↑ Rosendahl J, Witt H, Szmola R, Bhatia E, Ozsvári B, Landt O, Schulz HU, Gress TM, Pfützer R, Löhr M, Kovacs P, Blüher M, Stumvoll M, Choudhuri G, Hegyi P, te Morsche RH, Drenth JP, Truninger K, Macek M, Puhl G, Witt U, Schmidt H, Büning C, Ockenga J, Kage A, Groneberg DA, Nickel R, Berg T, Wiedenmann B, Bödeker H, Keim V, Mössner J, Teich N, Sahin-Tóth M (2008). "Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis". Nat. Genet. 40 (1): 78–82. doi:10.1038/ng.2007.44. PMC 2650829. PMID 18059268.
- ↑ Masson E, Chen JM, Scotet V, Le Maréchal C, Férec C (2008). "Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitis". Hum. Genet. 123 (1): 83–91. doi:10.1007/s00439-007-0459-3. PMID 18172691.
- ↑ LaRusch J, Lozano-Leon A, Stello K, Moore A, Muddana V, O'Connell M, Diergaarde B, Yadav D, Whitcomb DC (2015). "The Common Chymotrypsinogen C (CTRC) Variant G60G (C.180T) Increases Risk of Chronic Pancreatitis But Not Recurrent Acute Pancreatitis in a North American Population". Clin Transl Gastroenterol. 6: e68. doi:10.1038/ctg.2014.13. PMC 4418406. PMID 25569187.
- ↑ Beer S, Zhou J, Szabó A, Keiles S, Chandak GR, Witt H, Sahin-Tóth M (2013). "Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk". Gut. 62 (11): 1616–24. doi:10.1136/gutjnl-2012-303090. PMC 3660471. PMID 22942235.