Autoimmune hepatitis differential diagnosis: Difference between revisions
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{{CMG}} ;{{AE}} :{{MKK}} | {{CMG}} ;{{AE}} :{{MKK}} | ||
==Overview== | ==Overview== | ||
Autoimmune hepatitis must be differentiated from [[Hepatitis A,B,C, E]], [Drug induced hepatitis], and [ | Autoimmune hepatitis must be differentiated from [[Hepatitis A,B,C, E]], [[Drug induced hepatitis]],[[CMV hepatitis]], [[EBV]] hepatitis, Alcoholic hepatitis, [[Primary biliary cirrhosis]] and [[Primary sclerosing cholangitis]]. | ||
==Differentiating X from other Diseases== | ==Differentiating X from other Diseases== | ||
*[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3]. | *[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3]. |
Revision as of 19:43, 1 January 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ;Associate Editor(s)-in-Chief: :Manpreet Kaur, MD [2]
Overview
Autoimmune hepatitis must be differentiated from Hepatitis A,B,C, E, Drug induced hepatitis,CMV hepatitis, EBV hepatitis, Alcoholic hepatitis, Primary biliary cirrhosis and Primary sclerosing cholangitis.
Differentiating X from other Diseases
- [Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].
- [Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].
- As [disease name] manifests in a variety of clinical forms, differentiation must be established in accordance with the particular subtype. [Subtype name 1] must be differentiated from other diseases that cause [clinical feature 1], such as [differential dx1] and [differential dx2]. In contrast, [subtype name 2] must be differentiated from other diseases that cause [clinical feature 2], such as [differential dx3] and [differential dx4].
Autoimuune hepatitis must be differentiated from other conditions that may cause fatigue, nausea and vomiting, jaundice and elevated liver enzymes.
Disease | Clinical manifestations | Laboratory findings | Additional findings | |||||||
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Symptoms | Signs | Transaminitis (elevated AST and ALT) | Viral markers | Autoimmune markers | ||||||
Nausea & vomiting | Abdominal pain | Arthralgia | Jaundice | Hepatomegaly | ||||||
Acute viral hepatitis | Hepatitis A | +++ | ++ | + | +++ | + | +++ | HAV Ab | --- |
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Hepatitis B | +++ | ++ | ++ | +++ | + | +++ | HBs Ag, HBc Ab, HBe Ag | --- |
| |
Hepatitis C | +++ | ++ | ++ | +++ | + | +++ | HCV Ab | --- |
| |
Hepatitis E | ++ | ++ | +/- | ++ | + | +++ | HEV Ab | --- |
| |
CMV hepatitis | +/- | ++ | - | + | + | ++ | CMV-specific immunoglobulin (Ig)M antibody | -- |
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EBV hepatitis | +/- | ++ | - | +/- | + | ++ | Heterophile antibody test, monospot test | -- |
| |
Autoimmune hepatitis | - | + | +/- | ++ | + | +++ | --- | ANA, ASMA, anti SLA/LP, ANCA, ALKM-1 antibodies |
| |
Alcoholic hepatitis | +/- | + | - | + | - | AST>ALT | --- | --- |
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Drug induced hepatitis | +/- | + | - | + | + | ++ | --- | --- |
| |
Primary biliary cirrhosis | - | + | +/- | ++ | + | +++ | --- | anti-mitochondrial antibodies (AMAs) |
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Primary sclerosing cholangitis | - | + | +/- | ++ | + | +++ | --- | anti-mitochondrial antibodies (AMAs) |
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