Autoimmune hepatitis differential diagnosis: Difference between revisions
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* May cause either cholestatic or hepatocellular injury | * May cause either cholestatic or hepatocellular injury | ||
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| colspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" | | | colspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |Primary biliary cirrhosis | ||
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Revision as of 19:22, 29 December 2017
Autoimmune hepatitis Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Differentiating Autoimmune Hepatitis from other Diseases
- Autoimmune liver disease
- Primary biliary cirrhosis
- Primary sclerosing cholangitis
- Overlap syndrome
- Autoimmune cholangiopathy
- Chronic viral hepatitis
- Chronic hepatitis B
- Chronic hepatitis C
- Chronic hepatitis delta
- Chronic hepatitis due to other viruses
- Chronic drug-induced hepatitis
- Alpha-1 antitrypsin deficiency
- Wilson's disease
- Cholangiography related to the acquired immunodeficiency syndrome
- Granulomatous hepatitis
- Systemic lupus erythematosus
- Graft-versus-host disease
- Alcoholic steatohepatitis
- Nonalcoholic steatohepatitis
Hepatitis must be differentiated from other conditions that may cause fever, fatigue, nausea and vomiting, and elevated liver enzymes.
Disease | Clinical manifestations | Laboratory findings | Additional findings | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Symptoms | Signs | Transaminitis (elevated AST and ALT) | Viral markers | Autoimmune markers | ||||||
Nausea & vomiting | Abdominal pain | Arthralgia | Jaundice | Hepatomegaly | ||||||
Acute viral hepatitis | Hepatitis A | +++ | ++ | + | +++ | + | +++ | HAV Ab | --- |
|
Hepatitis B | +++ | ++ | ++ | +++ | + | +++ | HBs Ag, HBc Ab, HBe Ag | --- |
| |
Hepatitis C | +++ | ++ | ++ | +++ | + | +++ | HCV Ab | --- |
| |
Hepatitis E | ++ | ++ | +/- | ++ | + | +++ | HEV Ab | --- |
| |
CMV hepatitis | +/- | ++ | - | + | + | ++ | CMV-specific immunoglobulin (Ig)M antibody | -- |
| |
EBV hepatitis | +/- | ++ | - | +/- | + | ++ | Heterophile antibody test, monospot test | -- |
| |
Autoimmune hepatitis | - | + | +/- | ++ | + | +++ | --- | ANA, ASMA, anti SLA/LP, ANCA, ALKM-1 antibodies |
| |
Alcoholic hepatitis | +/- | + | - | + | - | AST>ALT | --- | --- |
| |
Drug induced hepatitis | +/- | + | - | + | + | ++ | --- | --- |
| |
Primary biliary cirrhosis | - | + | +/- | ++ | + | +++ | --- | ANA, ASMA, anti SLA/LP, ANCA, ALKM-1 antibodies |
|