CDH15: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Cadherin-15''' is a [[protein]] that in humans is encoded by the ''CDH15'' [[gene]].<ref name="pmid1427864">{{cite journal | vauthors = Kaupmann K, Becker-Follmann J, Scherer G, Jockusch H, Starzinski-Powitz A | title = The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species | journal = Genomics | volume = 14 | issue = 2 | pages = 488–90 | date = December 1992 | pmid = 1427864 | pmc =  | doi = 10.1016/S0888-7543(05)80247-2 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CDH15 cadherin 15, M-cadherin (myotubule)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1013| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cadherin 15, M-cadherin (myotubule)
| HGNCid = 1754
| Symbol = CDH15
| AltSymbols =; MCAD; CDH3; CDH14; CDHM
| OMIM = 114019
| ECnumber = 
| Homologene = 3622
| MGIid = 106672
| GeneAtlas_image1 = PBB_GE_CDH15_206327_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CDH15_206328_at_tn.png
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007156 |text = homophilic cell adhesion}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1013
    | Hs_Ensembl = ENSG00000129910
    | Hs_RefseqProtein = NP_004924
    | Hs_RefseqmRNA = NM_004933
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 87765664
    | Hs_GenLoc_end = 87789400
    | Hs_Uniprot = P55291
    | Mm_EntrezGene = 12555
    | Mm_Ensembl = ENSMUSG00000031962
    | Mm_RefseqmRNA = NM_007662
    | Mm_RefseqProtein = NP_031688
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 125734056
    | Mm_GenLoc_end = 125753487
    | Mm_Uniprot = P33146
  }}
}}
'''Cadherin 15, M-cadherin (myotubule)''', also known as '''CDH15''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CDH15 cadherin 15, M-cadherin (myotubule)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1013| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene is a member of the [[cadherin]] superfamily of genes, encoding calcium-dependent intercellular adhesion [[glycoprotein]]s. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in [[myoblast]]s and upregulated in [[myotubule]]-forming cells. The protein is thought to be essential for the control of [[morphogenetic]] processes, specifically [[myogenesis]], and may provide a trigger for terminal muscle cell differentiation.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation.<ref name="entrez">{{cite web | title = Entrez Gene: CDH15 cadherin 15, M-cadherin (myotubule)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1013| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
CDH15 has been shown to [[Protein-protein interaction|interact]] with [[ARVCF]].<ref name=pmid11058098>{{cite journal | vauthors = Kaufmann U, Zuppinger C, Waibler Z, Rudiger M, Urbich C, Martin B, Jockusch BM, Eppenberger H, Starzinski-Powitz A | title = The armadillo repeat region targets ARVCF to cadherin-based cellular junctions | language =  | journal = J. Cell Sci. | volume = 113 | issue = 22 | pages = 4121–35 | date = November 2000 | pmid = 11058098 }}</ref>
 
== References ==
{{reflist}}
{{Clear}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Donalies M, Cramer M, Ringwald M, Starzinski-Powitz A | title = Expression of M-cadherin, a member of the cadherin multigene family, correlates with differentiation of skeletal muscle cells. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 88 | issue = 18 | pages = 8024–8 | year = 1991 | pmid = 1840697 | pmc = 52438 | doi = 10.1073/pnas.88.18.8024 }}
| citations =
* {{cite journal | vauthors = Bornemann A, Schmalbruch H | title = Immunocytochemistry of M-cadherin in mature and regenerating rat muscle. | journal = Anat. Rec. | volume = 239 | issue = 2 | pages = 119–25 | year = 1994 | pmid = 8059975 | doi = 10.1002/ar.1092390202 }}
*{{cite journal | author=Kaupmann K, Becker-Follmann J, Scherer G, ''et al.'' |title=The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species. |journal=Genomics |volume=14 |issue= 2 |pages= 488-90 |year= 1992 |pmid= 1427864 |doi=  }}
* {{cite journal | vauthors = Shibata T, Shimoyama Y, Gotoh M, Hirohashi S | title = Identification of human cadherin-14, a novel neurally specific type II cadherin, by protein interaction cloning. | journal = J. Biol. Chem. | volume = 272 | issue = 8 | pages = 5236–40 | year = 1997 | pmid = 9030594 | doi = 10.1074/jbc.272.8.5236 }}
*{{cite journal  | author=Donalies M, Cramer M, Ringwald M, Starzinski-Powitz A |title=Expression of M-cadherin, a member of the cadherin multigene family, correlates with differentiation of skeletal muscle cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 18 |pages= 8024-8 |year= 1991 |pmid= 1840697 |doi= }}
* {{cite journal | vauthors = Kuch C, Winnekendonk D, Butz S, Unvericht U, Kemler R, Starzinski-Powitz A | title = M-cadherin-mediated cell adhesion and complex formation with the catenins in myogenic mouse cells. | journal = Exp. Cell Res. | volume = 232 | issue = 2 | pages = 331–8 | year = 1997 | pmid = 9168809 | doi = 10.1006/excr.1997.3519 }}
*{{cite journal | author=Bornemann A, Schmalbruch H |title=Immunocytochemistry of M-cadherin in mature and regenerating rat muscle. |journal=Anat. Rec. |volume=239 |issue= 2 |pages= 119-25 |year= 1994 |pmid= 8059975 |doi= 10.1002/ar.1092390202 }}
* {{cite journal | vauthors = Shimoyama Y, Shibata T, Kitajima M, Hirohashi S | title = Molecular cloning and characterization of a novel human classic cadherin homologous with mouse muscle cadherin. | journal = J. Biol. Chem. | volume = 273 | issue = 16 | pages = 10011–8 | year = 1998 | pmid = 9545347 | doi = 10.1074/jbc.273.16.10011 }}
*{{cite journal | author=Shibata T, Shimoyama Y, Gotoh M, Hirohashi S |title=Identification of human cadherin-14, a novel neurally specific type II cadherin, by protein interaction cloning. |journal=J. Biol. Chem. |volume=272 |issue= 8 |pages= 5236-40 |year= 1997 |pmid= 9030594 |doi= }}
* {{cite journal | vauthors = Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF | title = Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity. | journal = Genomics | volume = 49 | issue = 3 | pages = 467–71 | year = 1998 | pmid = 9615235 | doi = 10.1006/geno.1998.5281 }}
*{{cite journal | author=Kuch C, Winnekendonk D, Butz S, ''et al.'' |title=M-cadherin-mediated cell adhesion and complex formation with the catenins in myogenic mouse cells. |journal=Exp. Cell Res. |volume=232 |issue= 2 |pages= 331-8 |year= 1997 |pmid= 9168809 |doi= 10.1006/excr.1997.3519 }}
* {{cite journal | vauthors = Shimoyama Y, Tsujimoto G, Kitajima M, Natori M | title = Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins. | journal = Biochem. J. | volume = 349 | issue = Pt 1 | pages = 159–67 | year = 2001 | pmid = 10861224 | pmc = 1221133 | doi = 10.1042/0264-6021:3490159 }}
*{{cite journal | author=Shimoyama Y, Shibata T, Kitajima M, Hirohashi S |title=Molecular cloning and characterization of a novel human classic cadherin homologous with mouse muscle cadherin. |journal=J. Biol. Chem. |volume=273 |issue= 16 |pages= 10011-8 |year= 1998 |pmid= 9545347 |doi= }}
* {{cite journal | vauthors = Kaufmann U, Zuppinger C, Waibler Z, Rudiger M, Urbich C, Martin B, Jockusch BM, Eppenberger H, Starzinski-Powitz A | title = The armadillo repeat region targets ARVCF to cadherin-based cellular junctions. | journal = J. Cell Sci. | volume = 113 | issue = 22 | pages = 4121–35 | year = 2001 | pmid = 11058098 | doi =  }}
*{{cite journal | author=Kremmidiotis G, Baker E, Crawford J, ''et al.'' |title=Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity. |journal=Genomics |volume=49 |issue= 3 |pages= 467-71 |year= 1998 |pmid= 9615235 |doi= 10.1006/geno.1998.5281 }}
* {{cite journal | vauthors = Meigs TE, Fields TA, McKee DD, Casey PJ | title = Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 2 | pages = 519–24 | year = 2001 | pmid = 11136230 | pmc = 14619 | doi = 10.1073/pnas.021350998 }}
*{{cite journal | author=Shimoyama Y, Tsujimoto G, Kitajima M, Natori M |title=Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins. |journal=Biochem. J. |volume=349 |issue= Pt 1 |pages= 159-67 |year= 2001 |pmid= 10861224 |doi= }}
* {{cite journal | vauthors = Hollnagel A, Grund C, Franke WW, Arnold HH | title = The cell adhesion molecule M-cadherin is not essential for muscle development and regeneration. | journal = Mol. Cell. Biol. | volume = 22 | issue = 13 | pages = 4760–70 | year = 2002 | pmid = 12052883 | pmc = 133893 | doi = 10.1128/MCB.22.13.4760-4770.2002 }}
*{{cite journal | author=Kaufmann U, Zuppinger C, Waibler Z, ''et al.'' |title=The armadillo repeat region targets ARVCF to cadherin-based cellular junctions. |journal=J. Cell. Sci. |volume=113 ( Pt 22) |issue= |pages= 4121-35 |year= 2001 |pmid= 11058098 |doi=  }}
* {{cite journal | vauthors = Kang JS, Feinleib JL, Knox S, Ketteringham MA, Krauss RS | title = Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 7 | pages = 3989–94 | year = 2003 | pmid = 12634428 | pmc = 153035 | doi = 10.1073/pnas.0736565100 }}
*{{cite journal | author=Meigs TE, Fields TA, McKee DD, Casey PJ |title=Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 2 |pages= 519-24 |year= 2001 |pmid= 11136230 |doi= 10.1073/pnas.021350998 }}
*{{cite journal | author=Hollnagel A, Grund C, Franke WW, Arnold HH |title=The cell adhesion molecule M-cadherin is not essential for muscle development and regeneration. |journal=Mol. Cell. Biol. |volume=22 |issue= 13 |pages= 4760-70 |year= 2002 |pmid= 12052883 |doi= }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Kang JS, Feinleib JL, Knox S, ''et al.'' |title=Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 7 |pages= 3989-94 |year= 2003 |pmid= 12634428 |doi= 10.1073/pnas.0736565100 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
* {{UCSC genome browser|CDH15}}
* {{UCSC gene details|CDH15}}
* {{UCSC gene info|CDH3}}
 
{{Cell adhesion molecules}}
 
 
{{gene-16-stub}}

Latest revision as of 19:31, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Cadherin-15 is a protein that in humans is encoded by the CDH15 gene.[1][2]

Function

This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation.[2]

Interactions

CDH15 has been shown to interact with ARVCF.[3]

References

  1. ↑ Kaupmann K, Becker-Follmann J, Scherer G, Jockusch H, Starzinski-Powitz A (December 1992). "The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species". Genomics. 14 (2): 488–90. doi:10.1016/S0888-7543(05)80247-2. PMID 1427864.
  2. ↑ 2.0 2.1 "Entrez Gene: CDH15 cadherin 15, M-cadherin (myotubule)".
  3. ↑ Kaufmann U, Zuppinger C, Waibler Z, Rudiger M, Urbich C, Martin B, Jockusch BM, Eppenberger H, Starzinski-Powitz A (November 2000). "The armadillo repeat region targets ARVCF to cadherin-based cellular junctions". J. Cell Sci. 113 (22): 4121–35. PMID 11058098.

Further reading

External links


Retrieved from "https://www.wikidoc.org/index.php?title=CDH15&oldid=1417410"