TSPAN4: Difference between revisions

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Identifiers
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External IDs	GeneCards: [1]
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Latest revision as of 21:03, 8 November 2017

Tetraspanin-4 is a protein that in humans is encoded by the TSPAN4 gene.^[1]^[2]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified.^[2]

Interactions

TSPAN4 has been shown to interact with CD9,^[1] ITGA6,^[1] CD29,^[1] CD49c^[1] and CD81.^[1]

References

↑ ^{Jump up to: 1.0} ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME (Dec 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". J Biol Chem. 272 (46): 29181–9. doi:10.1074/jbc.272.46.29181. PMID 9360996.
↑ ^{Jump up to: 2.0} ^2.1 "Entrez Gene: TSPAN4 tetraspanin 4".

Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye". J. Cell Sci. 114 (Pt 23): 4143–51. PMID 11739647.
Todd SC, Doctor VS, Levy S (1998). "Sequences and expression of six new members of the tetraspanin/TM4SF family". Biochim. Biophys. Acta. 1399 (1): 101–4. doi:10.1016/s0167-4781(98)00087-6. PMID 9714763.
Serru V, Le Naour F, Billard M, et al. (1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions". Biochem. J. 340 (1): 103–11. doi:10.1042/0264-6021:3400103. PMC 1220227. PMID 10229664.
Yauch RL, Kazarov AR, Desai B, et al. (2000). "Direct extracellular contact between integrin alpha(3)beta(1) and TM4SF protein CD151". J. Biol. Chem. 275 (13): 9230–8. doi:10.1074/jbc.275.13.9230. PMID 10734060.
Lozahic S, Christiansen D, Manié S, et al. (2000). "CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans". Eur. J. Immunol. 30 (3): 900–7. doi:10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X. PMID 10741407.
Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark AG, Glanowski S, Nielsen R, et al. (2003). "Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios". Science. 302 (5652): 1960–3. doi:10.1126/science.1088821. PMID 14671302.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

[pmid9360996-1] {Jump up to: 1.0} ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME (Dec 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". J Biol Chem. 272 (46): 29181–9. doi:10.1074/jbc.272.46.29181. PMID 9360996.

[entrez-2] {Jump up to: 2.0} ^2.1 "Entrez Gene: TSPAN4 tetraspanin 4".

[1]

[2]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Tetraspanin-4''' is a [[protein]] that in humans is encoded by the ''TSPAN4'' [[gene]].<ref name="pmid9360996">{{cite journal | vauthors = Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME | title = NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins | journal = J Biol Chem | volume = 272 | issue = 46 | pages = 29181–9 |date=Dec 1997 | pmid = 9360996 | pmc =  | doi =10.1074/jbc.272.46.29181  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TSPAN4 tetraspanin 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7106| accessdate = }}</ref>
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-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Tetraspanin 4
- | HGNCid = 11859
- | Symbol = TSPAN4
- | AltSymbols =; NAG-2; NAG2; TETRASPAN; TM4SF7; TSPAN-4
- | OMIM = 602644
- | ECnumber =
- | Homologene = 2453
- | MGIid = 1928097
- | GeneAtlas_image1 = PBB_GE_TSPAN4_209264_s_at_tn.png
- | GeneAtlas_image2 = PBB_GE_TSPAN4_209263_x_at_tn.png
- | Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
- | Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
-  | Process = {{GNF_GO|id=GO:0006461 |text = protein complex assembly}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 7106
-    | Hs_Ensembl = ENSG00000177769
-    | Hs_RefseqProtein = NP_001020405
-    | Hs_RefseqmRNA = NM_001025234
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 11
-    | Hs_GenLoc_start = 832824
-    | Hs_GenLoc_end = 857116
-    | Hs_Uniprot = O14817
-    | Mm_EntrezGene = 64540
-    | Mm_Ensembl = ENSMUSG00000025511
-    | Mm_RefseqmRNA = NM_053082
-    | Mm_RefseqProtein = NP_444312
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 7
-    | Mm_GenLoc_start = 141326560
-    | Mm_GenLoc_end = 141344742
-    | Mm_Uniprot = Q4FJW7
-  }}
-}}
-'''Tetraspanin 4''', also known as '''TSPAN4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TSPAN4 tetraspanin 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7106| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: TSPAN4 tetraspanin 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7106| accessdate = }}</ref>
+| summary_text = The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref name="entrez" />
 }}
+==Interactions==
+TSPAN4 has been shown to [[Protein-protein interaction|interact]] with [[CD9]],<ref name=pmid9360996  /> [[ITGA6]],<ref name=pmid9360996/> [[CD29]],<ref name=pmid9360996/> [[CD49c]]<ref name=pmid9360996/> and [[CD81]].<ref name=pmid9360996/>
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Berditchevski F |title=Complexes of tetraspanins with integrins: more than meets the eye. |journal=J. Cell. Sci. |volume=114 |issue= Pt 23 |pages= 4143-51 |year= 2002 |pmid= 11739647 |doi=  }}
+*{{cite journal  | author=Berditchevski F |title=Complexes of tetraspanins with integrins: more than meets the eye. |journal=J. Cell Sci. |volume=114 |issue= Pt 23 |pages= 4143–51 |year= 2002 |pmid= 11739647 |doi=  }}
-*{{cite journal  | author=Tachibana I, Bodorova J, Berditchevski F, ''et al.'' |title=NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins. |journal=J. Biol. Chem. |volume=272 |issue= 46 |pages= 29181-9 |year= 1997 |pmid= 9360996 |doi=  }}
+*{{cite journal  | vauthors=Todd SC, Doctor VS, Levy S |title=Sequences and expression of six new members of the tetraspanin/TM4SF family. |journal=Biochim. Biophys. Acta |volume=1399 |issue= 1 |pages= 101–4 |year= 1998 |pmid= 9714763 |doi=  10.1016/s0167-4781(98)00087-6}}
-*{{cite journal  | author=Todd SC, Doctor VS, Levy S |title=Sequences and expression of six new members of the tetraspanin/TM4SF family. |journal=Biochim. Biophys. Acta |volume=1399 |issue= 1 |pages= 101-4 |year= 1998 |pmid= 9714763 |doi=  }}
+*{{cite journal   |vauthors=Serru V, Le Naour F, Billard M, etal |title=Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions.  | volume=340 |journal=Biochem. J. |issue=  1|pages= 103–11 |year= 1999 |pmid= 10229664 |doi=10.1042/0264-6021:3400103  | pmc=1220227  }}
-*{{cite journal  | author=Serru V, Le Naour F, Billard M, ''et al.'' |title=Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions. |journal=Biochem. J. |volume=340 ( Pt 1) |issue=  |pages= 103-11 |year= 1999 |pmid= 10229664 |doi=  }}
+*{{cite journal   |vauthors=Yauch RL, Kazarov AR, Desai B, etal |title=Direct extracellular contact between integrin alpha(3)beta(1) and TM4SF protein CD151. |journal=J. Biol. Chem. |volume=275 |issue= 13 |pages= 9230–8 |year= 2000 |pmid= 10734060 |doi=10.1074/jbc.275.13.9230  }}
-*{{cite journal  | author=Yauch RL, Kazarov AR, Desai B, ''et al.'' |title=Direct extracellular contact between integrin alpha(3)beta(1) and TM4SF protein CD151. |journal=J. Biol. Chem. |volume=275 |issue= 13 |pages= 9230-8 |year= 2000 |pmid= 10734060 |doi=  }}
+*{{cite journal   |vauthors=Lozahic S, Christiansen D, Manié S, etal |title=CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans. |journal=Eur. J. Immunol. |volume=30 |issue= 3 |pages= 900–7 |year= 2000 |pmid= 10741407 |doi= 10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X }}
-*{{cite journal  | author=Lozahic S, Christiansen D, Manié S, ''et al.'' |title=CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans. |journal=Eur. J. Immunol. |volume=30 |issue= 3 |pages= 900-7 |year= 2000 |pmid= 10741407 |doi= 10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X }}
+*{{cite journal   |vauthors=Suzuki H, Fukunishi Y, Kagawa I, etal |title=Protein-protein interaction panel using mouse full-length cDNAs. |journal=Genome Res. |volume=11 |issue= 10 |pages= 1758–65 |year= 2001 |pmid= 11591653 |doi= 10.1101/gr.180101  | pmc=311163 }}
-*{{cite journal  | author=Suzuki H, Fukunishi Y, Kagawa I, ''et al.'' |title=Protein-protein interaction panel using mouse full-length cDNAs. |journal=Genome Res. |volume=11 |issue= 10 |pages= 1758-65 |year= 2001 |pmid= 11591653 |doi= 10.1101/gr.180101 }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Clark AG, Glanowski S, Nielsen R, etal |title=Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios. |journal=Science |volume=302 |issue= 5652 |pages= 1960–3 |year= 2003 |pmid= 14671302 |doi= 10.1126/science.1088821 }}
-*{{cite journal  | author=Clark AG, Glanowski S, Nielsen R, ''et al.'' |title=Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios. |journal=Science |volume=302 |issue= 5652 |pages= 1960-3 |year= 2003 |pmid= 14671302 |doi= 10.1126/science.1088821 }}
+*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
-*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
+*{{cite journal   |vauthors=Oh JH, Yang JO, Hahn Y, etal |title=Transcriptome analysis of human gastric cancer. |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942–54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2 }}
-*{{cite journal  | author=Oh JH, Yang JO, Hahn Y, ''et al.'' |title=Transcriptome analysis of human gastric cancer. |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942-54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2 }}
 }}
 {{refend}}
-{{protein-stub}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
-{{WikiDoc Sources}}
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
+{{Cell membrane proteins}}
+{{gene-11-stub}}

v t e Protein: cell membrane proteins (other than Cell surface receptor, enzymes, and cytoskeleton)
Arrestin	SAG ARRB1 ARRB2 ARR3
Membrane-spanning 4A	MS4A1 MS4A2 MS4A3 MS4A4A MS4A4E MS4A5 MS4A6A MS4A6E MS4A7 MS4A8B MS4A9 MS4A10 MS4A12 MS4A13 MS4A14 MS4A15 MS4A18
Myelin	Myelin basic protein PMP2 Myelin proteolipid protein PLP1 Myelin oligodendrocyte glycoprotein Myelin-associated glycoprotein Myelin protein zero
Pulmonary surfactant	Pulmonary surfactant-associated protein B Pulmonary surfactant-associated protein C
Tetraspanin	TSPAN1 TSPAN2 TSPAN3 TSPAN4 TSPAN5 TSPAN6 TSPAN7 TSPAN8 TSPAN9 TSPAN10 TSPAN11 TSPAN12 TSPAN13 TSPAN14 TSPAN15 TSPAN16 TSPAN17 TSPAN18 TSPAN19 TSPAN20 TSPAN21 TSPAN22 TSPAN23 TSPAN24 TSPAN25 TSPAN26 TSPAN27 TSPAN28 TSPAN29 TSPAN30 TSPAN31 TSPAN32 TSPAN33 TSPAN34
Other/ungrouped	Calnexin LDL-receptor-related protein-associated protein Neurofibromin 2 Presenilin PSEN1 PSEN2 HFE Phospholipid transfer proteins Dysferlin STRC OTOF
see also other cell membrane protein disorders

TSPAN4: Difference between revisions

Latest revision as of 21:03, 8 November 2017

Interactions

References

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