TSPAN31

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Tetraspanin-31 is a protein that in humans is encoded by the TSPAN31 gene.

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is thought to be involved in growth-related cellular processes. This gene is associated with tumorigenesis and osteosarcoma.

Further reading

• Wright MD, Tomlinson MG (1995). "The ins and outs of the transmembrane 4 superfamily". Immunol. Today. 15 (12): 588–94. doi:10.1016/0167-5699(94)90222-4. PMID 7531445.
• Meltzer PS, Jankowski SA, Dal Cin P, et al. (1992). "Identification and cloning of a novel amplified DNA sequence in human malignant fibrous histiocytoma derived from a region of chromosome 12 frequently rearranged in soft tissue tumors". Cell Growth Differ. 2 (10): 495–501. PMID 1661131.
• Jankowski SA, De Jong P, Meltzer PS (1995). "Genomic structure of SAS, a member of the transmembrane 4 superfamily amplified in human sarcomas". Genomics. 25 (2): 501–6. doi:10.1016/0888-7543(95)80051-M. PMID 7789984.
• Jankowski SA, Mitchell DS, Smith SH, et al. (1994). "SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins". Oncogene. 9 (4): 1205–11. PMID 8134123.
• Elkahloun AG, Krizman DB, Wang Z, et al. (1997). "Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers" (PDF). Genomics. 42 (2): 295–301. doi:10.1006/geno.1997.4727. PMID 9192850.
• Wunder JS, Eppert K, Burrow SR, et al. (1999). "Co-amplification and overexpression of CDK4, SAS and MDM2 occurs frequently in human parosteal osteosarcomas". Oncogene. 18 (3): 783–8. doi:10.1038/sj.onc.1202346. PMID 9989829.
• Ragazzini P, Gamberi G, Benassi MS, et al. (1999). "Analysis of SAS gene and CDK4 and MDM2 proteins in low-grade osteosarcoma". Cancer Detect. Prev. 23 (2): 129–36. doi:10.1046/j.1525-1500.1999.09907.x. PMID 10101594.
• Suzuki Y, Tsunoda T, Sese J, et al. (2001). "Identification and Characterization of the Potential Promoter Regions of 1031 Kinds of Human Genes". Genome Res. 11 (5): 677–84. doi:10.1101/gr.gr-1640r. PMC 311086. PMID 11337467.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Ragazzini P, Gamberi G, Pazzaglia L, et al. (2004). "Amplification of CDK4, MDM2, SAS and GLI genes in leiomyosarcoma, alveolar and embryonal rhabdomyosarcoma". Histol. Histopathol. 19 (2): 401–11. PMID 15024701.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.