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Revision as of 02:20, 27 November 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Assistant Editor(s)-In-Chief: Yazan Daaboul, M.D.

Overview

Prior to the introduction of cigarette smoking and industrial carcinogens, lung cancer was thought to be a rare disease. Of all tumors detected an autopsy, lung cancer accounted for only 1% of cancers in the 1800s.[1] The majority of cases of lung cancer were associated with occupational hazards due to radon exposure. The association between lung cancer and smoking was not defined until the mid-20th century.

Historical Perspective

  • The majority of cases of lung cancer were associated with occupational hazards. Death among miners was reported to be caused by Bergkrankheit (mountain sickness).[1]
  • In 1924, radon gas was first reported to be a prominent cause of lung cancer among miners.[1]
  • The association between lung cancer and smoking was not defined until the mid-20th century. The first reports between lung cancer and smoking were often confounded by gender, given that men were more likely to be smokers compared to women.
  • The 1969 handbook Springer Handbook of Special Pathology is considered the landmark publication that highlighted the role of smoking in the development of lung cancer in over 25 pages.[1]
  • Although chemotherapy had always been regarded to be ineffective in the management of lung cancer, cisplatin-based chemotherapy emerged in the 1980s and demonstrated modest efficacy in the reduction of tumor-related symptoms and improvement of quality of life.

References

  1. 1.0 1.1 1.2 1.3 Witschi H (2001). "A short history of lung cancer". Toxicological Sciences : an Official Journal of the Society of Toxicology. 64 (1): 4–6. PMID 11606795. Retrieved 2011-12-09. Unknown parameter |month= ignored (help)

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