Toxic multinodular goiter natural history, complications and prognosis: Difference between revisions
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===Natural History=== | ===Natural History=== | ||
*The symptoms of | *The symptoms of toxic multinodular goiter usually develop in the first/ second/ third decade of life, and start with symptoms such as ___. | ||
*The symptoms of (disease name) typically develop ___ years after exposure to ___. | *The symptoms of (disease name) typically develop ___ years after exposure to ___. | ||
*If left untreated, | *If left untreated, toxic multinodular goiter may progress to develop hyperthyroidism. | ||
*Untreated toxic multinodular goiter progresses slowly and initially presents with history of thyroid enlargement. | |||
*Thyroid enlargement is followed by a long period of subclinical hyperthyroidism. | |||
*Overt hyperthyroidism occurs late in the course of toxic multinodular goiter. | |||
**When hyperthyroidism is present cardiac symptoms are the most common presentation such as palpitations, tachycardia, heart failure and atrial fibrillation. | |||
** Over the course of time, toxic multinodular goiter may increase in size and can lead to compression of surrounding structures such as trachea, esophagus or external jugular vein. | |||
===Complications=== | ===Complications=== |
Revision as of 13:52, 10 October 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
- If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
- Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].
- Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.
Natural History, Complications, and Prognosis
Natural History
- The symptoms of toxic multinodular goiter usually develop in the first/ second/ third decade of life, and start with symptoms such as ___.
- The symptoms of (disease name) typically develop ___ years after exposure to ___.
- If left untreated, toxic multinodular goiter may progress to develop hyperthyroidism.
- Untreated toxic multinodular goiter progresses slowly and initially presents with history of thyroid enlargement.
- Thyroid enlargement is followed by a long period of subclinical hyperthyroidism.
- Overt hyperthyroidism occurs late in the course of toxic multinodular goiter.
- When hyperthyroidism is present cardiac symptoms are the most common presentation such as palpitations, tachycardia, heart failure and atrial fibrillation.
- Over the course of time, toxic multinodular goiter may increase in size and can lead to compression of surrounding structures such as trachea, esophagus or external jugular vein.
Complications
- Common complications of [disease name] include:
- [complication 1]
- [complication 2]
- [complication 3]
Prognosis
- Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.
- Depending on the extent of the [tumor/disease progression/etc.] at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor/good/excellent.
- The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with [disease/malignancy].
- [Subtype of disease/malignancy] is associated with the most favorable prognosis.
- The prognosis varies with the [characteristic] of tumor; [subtype of disease/malignancy] have the most favorable prognosis.