Toxic multinodular goiter causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sunny Kumar MD [2]

Overview

The progression to Toxic multinodular goiter usually involves the somatic gain-of-function mutations in the TSH receptor gene.

Causes

The causes of toxic multinodular goiter are as follows:

Genetic Causes

• The development of multi-nodular goiter is the result of multiple genetic base substitution mutations on exon 10 of chromosome 14q31.

Frequency of mutation	TSHr gene codon	base substitution	amino acid change
Common	486	ATC/ATG	Ile/Met
Common	632	ACC/ATC	Thr/Ile
Less common	619	GAT/GGT	Asp/Gly
Less common	623	GCC/GTC	Ala/Val
Less common	629	TTG/TTT	Leu/Phe
Less common	630	ATC/CTC	Ile/Leu
Less common	633	GAC/GAG	Asp/Glu
Less common	639	CCA/TCA	Pro/Ser

Causes by Organ System

Cardiovascular	No underlying causes
Chemical/Poisoning	No underlying causes
Dental	No underlying causes
Dermatologic	No underlying causes
Drug Side Effect	No underlying causes
Ear Nose Throat	No underlying causes
Endocrine	No underlying causes
Environmental	No underlying causes
Gastroenterologic	No underlying causes
Genetic	The development of multi-nodular goiter is the result of multiple genetic base substitution mutations on exon 10 of chromosome 14q31.
Hematologic	No underlying causes
Iatrogenic	No underlying causes
Infectious Disease	No underlying causes
Musculoskeletal/Orthopedic	No underlying causes
Neurologic	No underlying causes
Nutritional/Metabolic	No underlying causes
Obstetric/Gynecologic	No underlying causes
Oncologic	No underlying causes
Ophthalmologic	No underlying causes
Overdose/Toxicity	No underlying causes
Psychiatric	No underlying causes
Pulmonary	No underlying causes
Renal/Electrolyte	No underlying causes
Rheumatology/Immunology/Allergy	No underlying causes
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Miscellaneous	No underlying causes

Causes in Alphabetical Order

List the causes of the disease in alphabetical order.

• Genetic base substitution mutations on exon 10 of chromosome 14q31.
• Cause 2
• Cause 3
• Cause 4
• Cause 5
• Cause 6
• Cause 7
• Cause 8
• Cause 9
• Cause 10