Uveitis pathophysiology: Difference between revisions

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*Fuch's heterochromic iridocyclitis
*Fuch's heterochromic iridocyclitis
*Lyme Disease
*Lyme Disease
*Acquired Immunodeficiency Syndrome (AIDS)
*Herpes simplex
*Herpes simplex
*Cytomegalovirus
*Cytomegalovirus

Revision as of 13:51, 27 July 2016

Uveitis Microchapters

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Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Uveitis from other Diseases

Epidemiology and Demographics

Risk Factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Tarek Nafee, M.D. [2]

Overview

Pathogenesis

The exact pathogenesis of uveitis is not fully understood. It is thought that uveitis is mediated by either genetic factors, infectious agents, or autoimmune/inflammatory conditions. Up to 35% of cases of uveitis are idiopathic. (REFERENCES) For infectious etiologies of uveitis, it is postulated that the immune reaction directed against foreign molecules or antigens may injure the uveal tract vessels and cells.

When uveitis is found in association with autoimmune disorders, the mechanism may be a hypersensitivity reaction involving immune complex deposition within the uveal tract.

Genetics

Associated Conditions

  • Seronegative spondyloarthropathy
  • Sarcoidosis
  • Inflammatory bowel disease
  • Systemic Lupus Erythematosus (SLE)
  • Behçet's syndrome
  • Birdshot retinochoroidopathy
  • Juvenile Idiopathic Arthritis (JIA)
  • Vogt-Koyanagi-Harada
  • Fuch's heterochromic iridocyclitis
  • Lyme Disease
  • Acquired Immunodeficiency Syndrome (AIDS)
  • Herpes simplex
  • Cytomegalovirus
  • Syphilis
  • Toxoplasmosis
  • Toxocariasis
  • Tuberculosis
  • Rubella
  • Cat scratch disease (Bartonella spp.)

Gross Pathology

Anterior Uveitis
Intermediate Uveitis
Posterior Uveitis

Microscopic Pathology

Anterior Uveitis
Intermediate Uveitis
Posterior Uveitis


References

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