Mast cell tumor biopsy: Difference between revisions
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*Skin biopsy | *Skin biopsy | ||
*Bone marrow biopsy<ref name="MolderingsBrettner2011">{{cite journal|last1=Molderings|first1=Gerhard J|last2=Brettner|first2=Stefan|last3=Homann|first3=Jürgen|last4=Afrin|first4=Lawrence B|title=Mast cell activation disease: a concise practical guide for diagnostic workup and therapeutic options|journal=Journal of Hematology & Oncology|volume=4|issue=1|year=2011|pages=10|issn=1756-8722|doi=10.1186/1756-8722-4-10}}</ref> | *Bone marrow biopsy<ref name="MolderingsBrettner2011">{{cite journal|last1=Molderings|first1=Gerhard J|last2=Brettner|first2=Stefan|last3=Homann|first3=Jürgen|last4=Afrin|first4=Lawrence B|title=Mast cell activation disease: a concise practical guide for diagnostic workup and therapeutic options|journal=Journal of Hematology & Oncology|volume=4|issue=1|year=2011|pages=10|issn=1756-8722|doi=10.1186/1756-8722-4-10}}</ref> | ||
:* | :*Exclude hematologic non-mast cell lineage diseases | ||
:*Detect a possible accumulation of mast cells | |||
:*Detect possible morphologic/immunohistochemical/genetic pathological alterations of mast cells | |||
:* | |||
:* | |||
==References== | ==References== |
Revision as of 15:32, 7 March 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Biopsy
The diagnosis of systemic mastocytosis is established by demonstrating mast cell infiltration in an involved tissue, particularly the bone marrow, using special staining techniques or flow cytometry.[1]
- Skin biopsy
- Bone marrow biopsy[2]
- Exclude hematologic non-mast cell lineage diseases
- Detect a possible accumulation of mast cells
- Detect possible morphologic/immunohistochemical/genetic pathological alterations of mast cells
References
- ↑ Koenig, Martial; Morel, Jérôme; Reynaud, Jacqueline; Varvat, Cécile; Cathébras, Pascal (2008). "An unusual cause of spontaneous bleeding in the intensive care unit – mastocytosis: a case report". Cases Journal. 1 (1): 100. doi:10.1186/1757-1626-1-100. ISSN 1757-1626.
- ↑ Molderings, Gerhard J; Brettner, Stefan; Homann, Jürgen; Afrin, Lawrence B (2011). "Mast cell activation disease: a concise practical guide for diagnostic workup and therapeutic options". Journal of Hematology & Oncology. 4 (1): 10. doi:10.1186/1756-8722-4-10. ISSN 1756-8722.