Mast cell tumor physical examination

Jump to navigation Jump to search

Mast cell tumor Microchapters


Patient Information


Historical Perspective




Differentiating Mast Cell Tumor from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis


Diagnostic Study of Choice

Diagnostic criteria


History and Symptoms

Physical Examination

Laboratory Findings



Echocardiography or Ultrasound

CT Scan



Other Imaging Findings

Other Diagnostic Studies


Medical Therapy


Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Mast cell tumor physical examination On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides


American Roentgen Ray Society Images of Mast cell tumor physical examination

All Images
Echo & Ultrasound
CT Images

Ongoing Trials at Clinical

US National Guidelines Clearinghouse

NICE Guidance

FDA on Mast cell tumor physical examination

CDC on Mast cell tumor physical examination

Mast cell tumor physical examination in the news

Blogs on Mast cell tumor physical examination

Directions to Hospitals Treating Mast cell tumor

Risk calculators and risk factors for Mast cell tumor physical examination

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Jesus Rosario Hernandez, M.D. [2], Suveenkrishna Pothuru, M.B,B.S. [3]


Physical examination for mast cell tumor include inspection for a large assortment of types of skin lesions, testing for dermatographism (Darier's sign), and palpating for hepatosplenomegaly and lymphadenopathy.

Physical Examination

Vital signs


  • Urticaria pigmentosa:[1]
  • Fixed, reddish brown lesions appears as maculo-papules, plaques, nodules, or blisters.[2]
  • Urticaria Pigmentosa (UP) lesions tend to be larger, better delineated, and more hyperpigmented in children, as compared to adults, who tend to have numerous small lesions that coalesce to form mottled areas.
  • The trunk and thigh are more commonly involved with sparing of face, palms and soles.
  • Darier’s sign:[3]
  • Lesions urticate in response to physical irritation.
  • Localized erythema and urticaria erupts within short period of time (minutes) in response to physical irritation.
  • Diffuse Cutaneous Mastocytosis
  • Diffuse infiltrative yellow-orange xanthogranuloma-like subcutaneous nodules, or as a widespread urticarial eruption with bullae and redness.[2]
  • Telangiectasia macularis eruptiva perstans[4]
    • It is a rare form of mastocytosis, and presents as brownish macules and telangiectasia.
    • Not associated with pruritus and blistering.



  1. CAPLAN RM (February 1963). "The natural course of urticaria pigmentosa. Analysis and follow-up of 112 cases". Arch Dermatol. 87: 146–57. PMID 14018418.
  2. 2.0 2.1 Ferrante, Giuliana; Scavone, Valeria; Muscia, Maria; Adrignola, Emilia; Corsello, Giovanni; Passalacqua, Giovanni; La Grutta, Stefania (2015). "The care pathway for children with urticaria, angioedema, mastocytosis". World Allergy Organization Journal. 8 (1): 5. doi:10.1186/s40413-014-0052-x. ISSN 1939-4551.
  3. Soter NA (June 2000). "Mastocytosis and the skin". Hematol. Oncol. Clin. North Am. 14 (3): 537–55, vi. PMID 10909039.
  4. Williams KW, Metcalfe DD, Prussin C, Carter MC, Komarow HD (2014). "Telangiectasia macularis eruptiva perstans or highly vascularized urticaria pigmentosa?". J Allergy Clin Immunol Pract. 2 (6): 813–5. doi:10.1016/j.jaip.2014.07.002. PMC 4254445. PMID 25439382.