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*A mast cell originates from the [[bone marrow]] and is normally found throughout the [[connective tissue]] of the body.
*A mast cell originates from the [[bone marrow]] and is normally found throughout the [[connective tissue]] of the body.
*It is a normal component of the [[immune system]] and as it releases [[histamine]] it is associated with [[allergy|allergic reactions]].
*It is a normal component of the [[immune system]] and as it releases [[histamine]] it is associated with [[allergy|allergic reactions]].
*Mast cell [[granule]]s contain [[histamine]], [[heparin]], [[platelet-activating factor]], and other substances.<ref name=saph>{{cite journal |author=Brière C |title=Use of a reverse saphenous skin flap for the excision of a grade II mast cell tumor on the hind limb of a dog |journal=Can Vet J |volume=43 |issue=8 |pages=620-2 |year=2002 |id=PMID 12170840}}</ref> with a similar number in cats.<ref name=pathol>{{cite journal |author=Johnson T, Schulman F, Lipscomb T, Yantis L |title=Histopathology and biologic behavior of pleomorphic cutaneous mast cell tumors in fifteen cats |journal=Vet Pathol |volume=39 |issue=4 |pages=452-7 |year=2002 |id=PMID 12126148}}</ref>
*Mast cell [[granule]]s contain [[histamine]], [[heparin]], [[platelet-activating factor]], and other substances.<ref name=saph>{{cite journal |author=Brière C |title=Use of a reverse saphenous skin flap for the excision of a grade II mast cell tumor on the hind limb of a dog |journal=Can Vet J |volume=43 |issue=8 |pages=620-2 |year=2002 |id=PMID 12170840}}</ref>


==References==
==References==

Revision as of 15:16, 29 February 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Pathophysiology

Mast cells are bone marrow derived cells that are widely distributed in tissues. They store various biologically active mediators, such as heparin and histamine. Mediator release from mast cells has a central role in the development of type 1 hypersensitivity 1.

In systemic mastocytosis, abnormal proliferation and microscopic infiltration of mast cells involves skin, bone marrow, gastrointestinal tract, liver and spleen. It is thought that the effects of mastocytosis relate at least in part to mediator release 7.


References

  1. Brière C (2002). "Use of a reverse saphenous skin flap for the excision of a grade II mast cell tumor on the hind limb of a dog". Can Vet J. 43 (8): 620–2. PMID 12170840.

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