Multiple myeloma history and symptoms: Difference between revisions
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==History== | ==History== | ||
* | * When evaluating a patient for multiple myeloma, you should take a detailed history of the presenting symptom (duration, onset, progression), other associated symptoms, and medication review. Other specific areas of focus when obtaining the history, are outlined below: :<ref>Multiple myeloma. MedlinePlus (2015)http://www.wikidoc.org/index.php?title=Multiple_myeloma_risk_factors&action=edit§ion=2 Accessed on Septmeber, 20th 2015 </ref> | ||
* | **Reviewing past medical history for other plasma cell diseases. | ||
**Reviewing family history for any positive family member. | |||
**Review occupational history related to farming or oil industry. | |||
**Review any exposure to petroleum, radiation, or toxic chemicals. | |||
*A rise in total protein levels without a concomitant rise in albumin levels must make the physician suspicious for a possibility of multiple myeloma. | *A rise in total protein levels without a concomitant rise in albumin levels must make the physician suspicious for a possibility of multiple myeloma. | ||
==Common Symptoms== | ==Common Symptoms== | ||
Symptoms of multiple myeloma include:<ref>Multiple myeloma. Wikipedia (2015) https://en.wikipedia.org/wiki/Multiple_myeloma#Signs_and_symptoms Accessed on September, 20th 2015</ref> | Symptoms of multiple myeloma include:<ref>Multiple myeloma. Wikipedia (2015) https://en.wikipedia.org/wiki/Multiple_myeloma#Signs_and_symptoms Accessed on September, 20th 2015</ref> | ||
Revision as of 15:56, 20 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
The most common symptoms of multiple myeloma include fatigue, pallor, and bone pain.[1] However, the presenting symptoms of multiple myeloma may vary greatly due to involvement of many organ systems. The common symptoms of multiple myeloma can be remembered by the mnemonic CRAB - C = Calcium (elevated), R =Renal failure, A = Anemia, B = Bone lesions.[2]
History
- When evaluating a patient for multiple myeloma, you should take a detailed history of the presenting symptom (duration, onset, progression), other associated symptoms, and medication review. Other specific areas of focus when obtaining the history, are outlined below: :[3]
- Reviewing past medical history for other plasma cell diseases.
- Reviewing family history for any positive family member.
- Review occupational history related to farming or oil industry.
- Review any exposure to petroleum, radiation, or toxic chemicals.
- A rise in total protein levels without a concomitant rise in albumin levels must make the physician suspicious for a possibility of multiple myeloma.
Common Symptoms
Symptoms of multiple myeloma include:[4]
-
- Usually involves the spine and ribs, and worsens with activity.
- Persistent localized pain may indicate a pathological bone fracture
- Neurological symptoms
- Numbness
- muscle weakness
- Confusion
- Dizziness
- Headache
- visual changes
- Hypercalcemia
- Polyurea
- Polydypsia
- Constipation
- Bleeding
- Recurrent infections
References
- ↑ Multiple myeloma. Wikipedia (2015) https://en.wikipedia.org/wiki/Multiple_myeloma#Signs_and_symptoms Accessed on September, 20th 2015
- ↑ International Myeloma Working Group. Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. Br J Haematol 2003;121:749-57. PMID 12780789.
- ↑ Multiple myeloma. MedlinePlus (2015)http://www.wikidoc.org/index.php?title=Multiple_myeloma_risk_factors&action=edit§ion=2 Accessed on Septmeber, 20th 2015
- ↑ Multiple myeloma. Wikipedia (2015) https://en.wikipedia.org/wiki/Multiple_myeloma#Signs_and_symptoms Accessed on September, 20th 2015