Tuberculosis future or investigational therapies: Difference between revisions

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==Overview==
==Overview==
==Future investigations==
==Future investigations==
In future therapies the following questions must be pondered on.


1) How can we shorten chemotherapy?
===Principles of future investigations===
Any future regimen should satisfy the following principles.


2) How can the interval between the therapy reduced ?
* It should not have more than a maximum duration of 6 months
 
* The dosing schedule must be simple
3) How can new drugs be developed ?
* The number of drugs in it should be ideally not more than 3-5 drug each from a different class
 
* It should have minimum side effect profile so that we could have minimum monitoring
4) What is the best therapy for tuberculosis with HIV ?
* It should be effective against MDR, XDR and XXDR strains
 
* It should be administered per orally
5) Role of immunomodulation
* It should have minimum interaction with anti retroviral drugs.
* It should have atleast one new class of drug


===New drugs involved in clinical trial for treatment of tuberculosis===
===New drugs involved in clinical trial for treatment of tuberculosis===

Revision as of 15:02, 25 September 2014

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Overview

Future investigations

Principles of future investigations

Any future regimen should satisfy the following principles.

  • It should not have more than a maximum duration of 6 months
  • The dosing schedule must be simple
  • The number of drugs in it should be ideally not more than 3-5 drug each from a different class
  • It should have minimum side effect profile so that we could have minimum monitoring
  • It should be effective against MDR, XDR and XXDR strains
  • It should be administered per orally
  • It should have minimum interaction with anti retroviral drugs.
  • It should have atleast one new class of drug

New drugs involved in clinical trial for treatment of tuberculosis

Drug Phase Class}}
Moxifloxacin Phase III Fluoroquinolone
Linezolid Phase II Oxazolidinone
AZD-5847 Phase II Oxazolidinone
Sutezolid Phase II Oxazolidinone
Clofazimine Phase II Riminophenazine
SQ-109 Phase II Ethylenediamine
PA-824 Phase IIb Nitroimidazole
Delamanid Phase III Nitroimidazole
Bedaquiline Phase III Diarylquinoline
Data provided by WHO[1]

References

  1. "Tuberculosis (TB) Future drugs".

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