WBR0141: Difference between revisions
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{{WBRQuestion | {{WBRQuestion | ||
|QuestionAuthor={{Rim}} | |QuestionAuthor={{Rim}} {{Alison}} | ||
|ExamType=USMLE Step 1 | |ExamType=USMLE Step 1 | ||
|MainCategory=Immunology | |MainCategory=Immunology | ||
| Line 20: | Line 20: | ||
|MainCategory=Immunology | |MainCategory=Immunology | ||
|SubCategory=General Principles | |SubCategory=General Principles | ||
|Prompt=Neutrophils are critically involved in the inflammation | |Prompt=Neutrophils are critically involved in the process of inflammation. The sequence of events in the recruitment of neutrophils from the vessel lumen to the extracellular matrix, referred to as extravasation, and can be divided up into four steps. Which of the following signaling mediators is involved in the migration of the neutrophils across the endothelial cells? | ||
|Explination= | |||
|EducationalObjectives= | |||
|AnswerA=E selectin and P selectin | |AnswerA=E selectin and P selectin | ||
|AnswerAExp=[[E selectin]] and P selectin are involved in the rolling phase. | |AnswerAExp=[[E selectin]] and P selectin are involved in the rolling phase. | ||
| Line 32: | Line 36: | ||
|AnswerEExp=[[Interleukin]] 8 is involved in the migration of [[leukocytes]] through the interstitium towards the site of [[inflammation]]. | |AnswerEExp=[[Interleukin]] 8 is involved in the migration of [[leukocytes]] through the interstitium towards the site of [[inflammation]]. | ||
|EducationalObjectives=[[Inflammation]] involves several steps including the rolling phase of the [[neutrophils]], their binding to the [[endothelium]], [[diapedesis]] and migration to the site of inflammation. [[PECAM 1]] is involved in diapedesis, which is the migration of the leukocytes across the endothelial cells. | |EducationalObjectives=[[Inflammation]] involves several steps including the rolling phase of the [[neutrophils]], their binding to the [[endothelium]], [[diapedesis]] and migration to the site of inflammation. [[PECAM 1]] is involved in diapedesis, which is the migration of the leukocytes across the endothelial cells. | ||
|References=First Aid 2014 page 224 | |References= First Aid 2014 page 224 | ||
|RightAnswer=C | |RightAnswer=C | ||
|WBRKeyword=Inflammation, Diapedesis, Leukocyte, Leukocyte adhesion, Endothelium, Endothelial cell | |WBRKeyword=Inflammation, Diapedesis, Leukocyte, Leukocyte adhesion, Endothelium, Endothelial cell | ||
|Approved=No | |Approved=No | ||
}} | }} | ||
Revision as of 13:04, 10 July 2014
| Author | [[PageAuthor::Rim Halaby, M.D. [1] (Reviewed by Alison Leibowitz)]] |
|---|---|
| Exam Type | ExamType::USMLE Step 1 |
| Main Category | MainCategory::Immunology |
| Sub Category | SubCategory::General Principles |
| Prompt | [[Prompt::Neutrophils are critically involved in the process of inflammation. The sequence of events in the recruitment of neutrophils from the vessel lumen to the extracellular matrix, referred to as extravasation, and can be divided up into four steps. Which of the following signaling mediators is involved in the migration of the neutrophils across the endothelial cells?]] |
| Answer A | AnswerA::E selectin and P selectin |
| Answer A Explanation | [[AnswerAExp::E selectin and P selectin are involved in the rolling phase.]] |
| Answer B | AnswerB::ICAM 1 |
| Answer B Explanation | [[AnswerBExp::ICAM-1 is involved in the tight binding of neutrophils to the endothelium.]] |
| Answer C | AnswerC::PECAM 1 |
| Answer C Explanation | [[AnswerCExp::PECAM-1 is involved in diapedesis, which is the migration of the leukocytes across the endothelial cells.]] |
| Answer D | AnswerD::C5a |
| Answer D Explanation | [[AnswerDExp::C5 a is involved in the migration of leykocytes through the interstitum towards the site of inflammation.]] |
| Answer E | AnswerE::Interleukin 8 |
| Answer E Explanation | [[AnswerEExp::Interleukin 8 is involved in the migration of leukocytes through the interstitium towards the site of inflammation.]] |
| Right Answer | RightAnswer::C |
| Explanation | [[Explanation:: Educational Objective: Inflammation involves several steps including the rolling phase of the neutrophils, their binding to the endothelium, diapedesis and migration to the site of inflammation. PECAM 1 is involved in diapedesis, which is the migration of the leukocytes across the endothelial cells. |
| Approved | Approved::No |
| Keyword | WBRKeyword::Inflammation, WBRKeyword::Diapedesis, WBRKeyword::Leukocyte, WBRKeyword::Leukocyte adhesion, WBRKeyword::Endothelium, WBRKeyword::Endothelial cell |
| Linked Question | Linked:: |
| Order in Linked Questions | LinkedOrder:: |