Peripheral neuropathy natural history, complications and prognosis: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Peripheral neuropathy}} | {{Peripheral neuropathy}} | ||
{{CMG}}; {{AE}} {{MMJ}} | |||
==Overview== | |||
==Natural History, Complications, and Prognosis== | |||
===Natural History=== | |||
*The symptoms of peripheral neuropathy usually start with symptoms such as [[numbness]], [[prickling]] or [[tingling]] in [[feet]] or [[hands]], which can spread upward into [[legs]] and [[arms]]. | |||
*The symptoms of peripheral neuropathy typically develop five years after diagnosis of [[diabetes mellitus]]. Fifty percent of people with [[diabetes]] eventually develop diabetic peripheral neuropathy. | |||
===Complications=== | |||
*Common complications of peripheral neuropathy include:<ref name="pmid18615140">{{cite journal| author=Marchettini P, Lacerenza M, Mauri E, Marangoni C| title=Painful peripheral neuropathies. | journal=Curr Neuropharmacol | year= 2006 | volume= 4 | issue= 3 | pages= 175-81 | pmid=18615140 | doi= | pmc=2430688 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18615140 }} </ref><ref name="pmid18221439">{{cite journal| author=Karabouta Z, Barnett S, Shield JP, Ryan FJ, Crowne EC| title=Peripheral neuropathy is an early complication of type 2 diabetes in adolescence. | journal=Pediatr Diabetes | year= 2008 | volume= 9 | issue= 2 | pages= 110-4 | pmid=18221439 | doi=10.1111/j.1399-5448.2007.00339.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18221439 }} </ref><ref name="pmid1464245">{{cite journal| author=Greene DA, Sima AA, Stevens MJ, Feldman EL, Lattimer SA| title=Complications: neuropathy, pathogenetic considerations. | journal=Diabetes Care | year= 1992 | volume= 15 | issue= 12 | pages= 1902-25 | pmid=1464245 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1464245 }} </ref><ref name="pmid24298503">{{cite journal| author=Singh S, Chand G, Charan S, Arora S, Singh P| title=Peripheral arterial disease and digital gangrene: a rare presentation of diabetic hand syndrome. | journal=J Clin Diagn Res | year= 2013 | volume= 7 | issue= 10 | pages= 2286-7 | pmid=24298503 | doi=10.7860/JCDR/2013/5584.3498 | pmc=3843397 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24298503 }} </ref><ref name="pmid25279253">{{cite journal| author=Smith JK, Myers KP, Holloway RG, Landau ME| title=Ethical considerations in elective amputation after traumatic peripheral nerve injuries. | journal=Neurol Clin Pract | year= 2014 | volume= 4 | issue= 4 | pages= 280-286 | pmid=25279253 | doi=10.1212/CPJ.0000000000000049 | pmc=4160445 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25279253 }} </ref><ref name="pmid29359025">{{cite journal| author=Serhiyenko VA, Serhiyenko AA| title=Cardiac autonomic neuropathy: Risk factors, diagnosis and treatment. | journal=World J Diabetes | year= 2018 | volume= 9 | issue= 1 | pages= 1-24 | pmid=29359025 | doi=10.4239/wjd.v9.i1.1 | pmc=5763036 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29359025 }} </ref><ref name="pmid22190298">{{cite journal| author=Burakgazi AZ, Alsowaity B, Burakgazi ZA, Unal D, Kelly JJ| title=Bladder dysfunction in peripheral neuropathies. | journal=Muscle Nerve | year= 2012 | volume= 45 | issue= 1 | pages= 2-8 | pmid=22190298 | doi=10.1002/mus.22178 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22190298 }} </ref> | |||
**[[Foot ulcers]] | |||
**[[Gangrene]] of the [[limbs]] from [[infected]] [[wounds]] | |||
**[[Amputation]] from [[infected]] [[wounds]] | |||
**Cardiovascular automatic neuropathy | |||
**[[Gastroparesis]] | |||
**Bladder control loss | |||
**[[Fecal incontinence]] | |||
**[[Ataxia]] and frequent falls | |||
===Prognosis=== | |||
*Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [--]%. | |||
*Depending on the extent of the [tumor/disease progression] at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor/good/excellent. | |||
*The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with [disease/malignancy]. | |||
*[Subtype of disease/malignancy] is associated with the most favorable prognosis. | |||
*The prognosis varies with the [characteristic] of tumor; [subtype of disease/malignancy] have the most favorable prognosis. | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
{{WH}} | |||
{{WS}} | |||
[[Category: (name of the system)]] | |||
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Revision as of 17:08, 22 August 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]
Overview
Natural History, Complications, and Prognosis
Natural History
- The symptoms of peripheral neuropathy usually start with symptoms such as numbness, prickling or tingling in feet or hands, which can spread upward into legs and arms.
- The symptoms of peripheral neuropathy typically develop five years after diagnosis of diabetes mellitus. Fifty percent of people with diabetes eventually develop diabetic peripheral neuropathy.
Complications
- Common complications of peripheral neuropathy include:[1][2][3][4][5][6][7]
- Foot ulcers
- Gangrene of the limbs from infected wounds
- Amputation from infected wounds
- Cardiovascular automatic neuropathy
- Gastroparesis
- Bladder control loss
- Fecal incontinence
- Ataxia and frequent falls
Prognosis
- Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [--]%.
- Depending on the extent of the [tumor/disease progression] at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor/good/excellent.
- The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with [disease/malignancy].
- [Subtype of disease/malignancy] is associated with the most favorable prognosis.
- The prognosis varies with the [characteristic] of tumor; [subtype of disease/malignancy] have the most favorable prognosis.
References
- ↑ Marchettini P, Lacerenza M, Mauri E, Marangoni C (2006). "Painful peripheral neuropathies". Curr Neuropharmacol. 4 (3): 175–81. PMC 2430688. PMID 18615140.
- ↑ Karabouta Z, Barnett S, Shield JP, Ryan FJ, Crowne EC (2008). "Peripheral neuropathy is an early complication of type 2 diabetes in adolescence". Pediatr Diabetes. 9 (2): 110–4. doi:10.1111/j.1399-5448.2007.00339.x. PMID 18221439.
- ↑ Greene DA, Sima AA, Stevens MJ, Feldman EL, Lattimer SA (1992). "Complications: neuropathy, pathogenetic considerations". Diabetes Care. 15 (12): 1902–25. PMID 1464245.
- ↑ Singh S, Chand G, Charan S, Arora S, Singh P (2013). "Peripheral arterial disease and digital gangrene: a rare presentation of diabetic hand syndrome". J Clin Diagn Res. 7 (10): 2286–7. doi:10.7860/JCDR/2013/5584.3498. PMC 3843397. PMID 24298503.
- ↑ Smith JK, Myers KP, Holloway RG, Landau ME (2014). "Ethical considerations in elective amputation after traumatic peripheral nerve injuries". Neurol Clin Pract. 4 (4): 280–286. doi:10.1212/CPJ.0000000000000049. PMC 4160445. PMID 25279253.
- ↑ Serhiyenko VA, Serhiyenko AA (2018). "Cardiac autonomic neuropathy: Risk factors, diagnosis and treatment". World J Diabetes. 9 (1): 1–24. doi:10.4239/wjd.v9.i1.1. PMC 5763036. PMID 29359025.
- ↑ Burakgazi AZ, Alsowaity B, Burakgazi ZA, Unal D, Kelly JJ (2012). "Bladder dysfunction in peripheral neuropathies". Muscle Nerve. 45 (1): 2–8. doi:10.1002/mus.22178. PMID 22190298.