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{{Infobox_gene}}
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'''Paternally-expressed gene 3 protein''' is a [[protein]] that in humans is encoded by the ''Peg3'' [[gene]].<ref name="pmid9149948">{{cite journal |vauthors=Kim J, Ashworth L, Branscomb E, Stubbs L | title = The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc finger gene-rich region of human chromosome 19q13.4 | journal = Genome Res | volume = 7 | issue = 5 | pages = 532–40 |date=August 1997 | pmid = 9149948 | pmc = 310658 | doi =  10.1101/gr.7.5.532}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PEG3 paternally expressed 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5178| accessdate = }}</ref> Peg3 is an [[imprinted gene]] expressed exclusively from the paternal allele and plays important roles in controlling fetal growth rates and nurturing behaviors as has potential roles in mammalian reproduction.<ref>{{cite web|url=http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0083359|| volume = 8 | issue = 12 |author1=Michelle M. Thiaville |author2=Jennifer M. Huang |author3=Hana Kim |author4=Muhammad B. Ekram |author5=Arundhati Bakshi |author6=Tae-Young Roh |author7=Joomyeong Kim |date=December 31, 2013|| accessdate = May 22, 2014|title=Peg3 Mutational Effects on Reproduction and Placenta-Specific Gene Families}}</ref>  PEG3 is a transcription factor that binds to DNA [11-13] via the [[sequence motif]] AGTnnCnnnTGGCT, which it binds to using multiple [[Kruppel-like factors]]. It also regulate the expression of Pgm2l1 through the binding of the motif.<ref name="pmid23078764 ">{{cite journal |vauthors=Thiaville MM, Huang JM, Kim H, Ekram MB, Roh TY, Kim J | title = DNA-binding motif and target genes of the imprinted transcription factor PEG3 | journal = Gene | volume = 512 | issue = 2 | pages = 314–320 |date=January 2013 | pmid = 23078764 | pmc = 3513644 | doi = 10.1016/j.gene.2012.10.005}}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Paternally expressed 3
| HGNCid = 8826
| Symbol = PEG3
| AltSymbols =; DKFZp781A095; KIAA0287; PW1; ZSCAN24
| OMIM = 601483
| ECnumber =
| Homologene = 31363
  | MGIid = 104748
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006915 |text = apoptosis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5178
    | Hs_Ensembl =
    | Hs_RefseqProtein = NP_006201
    | Hs_RefseqmRNA = NM_006210
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr =
    | Hs_GenLoc_start =
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 18616
    | Mm_Ensembl = ENSMUSG00000002265
    | Mm_RefseqmRNA = NM_001010988
    | Mm_RefseqProtein = NP_001010988
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 6310046
    | Mm_GenLoc_end = 6334505
    | Mm_Uniprot = Q0P5Y8
  }}
}}
'''Paternally expressed 3''', also known as '''PEG3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PEG3 paternally expressed 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5178| accessdate = }}</ref>


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==Interactions==
PEG3 has been shown to [[Protein-protein interaction|interact]] with [[SIAH2]]<ref name=pmid10681424>{{cite journal |last=Relaix |first=F |authorlink= |author2=Wei X j |author3=Li W |author4=Pan J |author5=Lin Y |author6=Bowtell D D |author7=Sassoon D A |author8=Wu X  |date=February 2000  |title=Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=97 |issue=5 |pages=2105–10 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 10681424 |doi = 10.1073/pnas.040378897 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=15761 }}</ref> and [[SIAH1]].<ref name=pmid10681424/>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
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| citations =  
| citations =  
*{{cite journal  | author=Kim J, Ashworth L, Branscomb E, Stubbs L |title=The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc finger gene-rich region of human chromosome 19q13.4. |journal=Genome Res. |volume=7 |issue= 5 |pages= 532-40 |year= 1997 |pmid= 9149948 |doi=  }}
*{{cite journal  |vauthors=Relaix F, Wei XJ, Wu X, Sassoon DA |title=Peg3/Pw1 is an imprinted gene involved in the TNF-NFkappaB signal transduction pathway. |journal=Nat. Genet. |volume=18 |issue= 3 |pages= 287–91 |year= 1998 |pmid= 9500555 |doi= 10.1038/ng0398-287 }}
*{{cite journal  | author=Relaix F, Wei XJ, Wu X, Sassoon DA |title=Peg3/Pw1 is an imprinted gene involved in the TNF-NFkappaB signal transduction pathway. |journal=Nat. Genet. |volume=18 |issue= 3 |pages= 287-91 |year= 1998 |pmid= 9500555 |doi= 10.1038/ng0398-287 }}
*{{cite journal   |vauthors=Relaix F, Wei X, Li W, etal |title=Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 5 |pages= 2105–10 |year= 2000 |pmid= 10681424 |doi= 10.1073/pnas.040378897 | pmc=15761 }}
*{{cite journal | author=Relaix F, Wei X, Li W, ''et al.'' |title=Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 5 |pages= 2105-10 |year= 2000 |pmid= 10681424 |doi= 10.1073/pnas.040378897 }}
*{{cite journal  |vauthors=Kim J, Bergmann A, Stubbs L |title=Exon sharing of a novel human zinc-finger gene, ZIM2, and paternally expressed gene 3 (PEG3). |journal=Genomics |volume=64 |issue= 1 |pages= 114–8 |year= 2000 |pmid= 10708526 |doi= 10.1006/geno.1999.6112 }}
*{{cite journal  | author=Kim J, Bergmann A, Stubbs L |title=Exon sharing of a novel human zinc-finger gene, ZIM2, and paternally expressed gene 3 (PEG3). |journal=Genomics |volume=64 |issue= 1 |pages= 114-8 |year= 2000 |pmid= 10708526 |doi= 10.1006/geno.1999.6112 }}
*{{cite journal   |vauthors=Kohda T, Asai A, Kuroiwa Y, etal |title=Tumour suppressor activity of human imprinted gene PEG3 in a glioma cell line. |journal=Genes Cells |volume=6 |issue= 3 |pages= 237–47 |year= 2001 |pmid= 11260267 |doi=10.1046/j.1365-2443.2001.00412.x }}
*{{cite journal | author=Kohda T, Asai A, Kuroiwa Y, ''et al.'' |title=Tumour suppressor activity of human imprinted gene PEG3 in a glioma cell line. |journal=Genes Cells |volume=6 |issue= 3 |pages= 237-47 |year= 2001 |pmid= 11260267 |doi=  }}
*{{cite journal   |vauthors=Hiby SE, Lough M, Keverne EB, etal |title=Paternal monoallelic expression of PEG3 in the human placenta. |journal=Hum. Mol. Genet. |volume=10 |issue= 10 |pages= 1093–100 |year= 2001 |pmid= 11331620 |doi=10.1093/hmg/10.10.1093 }}
*{{cite journal | author=Hiby SE, Lough M, Keverne EB, ''et al.'' |title=Paternal monoallelic expression of PEG3 in the human placenta. |journal=Hum. Mol. Genet. |volume=10 |issue= 10 |pages= 1093-100 |year= 2001 |pmid= 11331620 |doi=  }}
*{{cite journal  |vauthors=Yarden RI, Brody LC |title=Identification of proteins that interact with BRCA1 by Far-Western library screening. |journal=J. Cell. Biochem. |volume=83 |issue= 4 |pages= 521–31 |year= 2002 |pmid= 11746496 |doi=10.1002/jcb.1257 }}
*{{cite journal  | author=Yarden RI, Brody LC |title=Identification of proteins that interact with BRCA1 by Far-Western library screening. |journal=J. Cell. Biochem. |volume=83 |issue= 4 |pages= 521-31 |year= 2002 |pmid= 11746496 |doi=  }}
*{{cite journal  |vauthors=Johnson MD, Wu X, Aithmitti N, Morrison RS |title=Peg3/Pw1 is a mediator between p53 and Bax in DNA damage-induced neuronal death. |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 23000–7 |year= 2002 |pmid= 11943780 |doi= 10.1074/jbc.M201907200 }}
*{{cite journal  | author=Johnson MD, Wu X, Aithmitti N, Morrison RS |title=Peg3/Pw1 is a mediator between p53 and Bax in DNA damage-induced neuronal death. |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 23000-7 |year= 2002 |pmid= 11943780 |doi= 10.1074/jbc.M201907200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Mirey G, Chartrain I, Froment C, etal |title=CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis. |journal=Cell Cycle |volume=4 |issue= 6 |pages= 806–11 |year= 2006 |pmid= 15908796 |doi=  10.4161/cc.4.6.1716}}
*{{cite journal | author=Mirey G, Chartrain I, Froment C, ''et al.'' |title=CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis. |journal=Cell Cycle |volume=4 |issue= 6 |pages= 806-11 |year= 2006 |pmid= 15908796 |doi=  }}
*{{cite journal   |vauthors=Dowdy SC, Gostout BS, Shridhar V, etal |title=Biallelic methylation and silencing of paternally expressed gene 3 (PEG3) in gynecologic cancer cell lines. |journal=Gynecol. Oncol. |volume=99 |issue= 1 |pages= 126–34 |year= 2005 |pmid= 16023706 |doi= 10.1016/j.ygyno.2005.05.036 }}
*{{cite journal | author=Dowdy SC, Gostout BS, Shridhar V, ''et al.'' |title=Biallelic methylation and silencing of paternally expressed gene 3 (PEG3) in gynecologic cancer cell lines. |journal=Gynecol. Oncol. |volume=99 |issue= 1 |pages= 126-34 |year= 2005 |pmid= 16023706 |doi= 10.1016/j.ygyno.2005.05.036 }}
*{{cite journal  |vauthors=Chartrain I, Couturier A, Tassan JP |title=Cell-cycle-dependent cortical localization of pEg3 protein kinase in Xenopus and human cells. |journal=Biol. Cell |volume=98 |issue= 4 |pages= 253–63 |year= 2006 |pmid= 16159311 |doi= 10.1042/BC20050041 }}
*{{cite journal  | author=Chartrain I, Couturier A, Tassan JP |title=Cell-cycle-dependent cortical localization of pEg3 protein kinase in Xenopus and human cells. |journal=Biol. Cell |volume=98 |issue= 4 |pages= 253-63 |year= 2006 |pmid= 16159311 |doi= 10.1042/BC20050041 }}
*{{cite journal   |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
}}
}}
{{refend}}
{{refend}}
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{{Transcription factors|g2}}


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Revision as of 17:54, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Paternally-expressed gene 3 protein is a protein that in humans is encoded by the Peg3 gene.[1][2] Peg3 is an imprinted gene expressed exclusively from the paternal allele and plays important roles in controlling fetal growth rates and nurturing behaviors as has potential roles in mammalian reproduction.[3] PEG3 is a transcription factor that binds to DNA [11-13] via the sequence motif AGTnnCnnnTGGCT, which it binds to using multiple Kruppel-like factors. It also regulate the expression of Pgm2l1 through the binding of the motif.[4]


Interactions

PEG3 has been shown to interact with SIAH2[5] and SIAH1.[5]

References

  1. ↑ Kim J, Ashworth L, Branscomb E, Stubbs L (August 1997). "The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc finger gene-rich region of human chromosome 19q13.4". Genome Res. 7 (5): 532–40. doi:10.1101/gr.7.5.532. PMC 310658. PMID 9149948.
  2. ↑ "Entrez Gene: PEG3 paternally expressed 3".
  3. ↑ Michelle M. Thiaville; Jennifer M. Huang; Hana Kim; Muhammad B. Ekram; Arundhati Bakshi; Tae-Young Roh; Joomyeong Kim (December 31, 2013). "Peg3 Mutational Effects on Reproduction and Placenta-Specific Gene Families". Retrieved May 22, 2014.
  4. ↑ Thiaville MM, Huang JM, Kim H, Ekram MB, Roh TY, Kim J (January 2013). "DNA-binding motif and target genes of the imprinted transcription factor PEG3". Gene. 512 (2): 314–320. doi:10.1016/j.gene.2012.10.005. PMC 3513644. PMID 23078764.
  5. ↑ 5.0 5.1 Relaix, F; Wei X j; Li W; Pan J; Lin Y; Bowtell D D; Sassoon D A; Wu X (February 2000). "Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 97 (5): 2105–10. doi:10.1073/pnas.040378897. ISSN 0027-8424. PMC 15761. PMID 10681424.

Further reading



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