Colorectal cancer natural history: Difference between revisions
No edit summary |
|||
Line 56: | Line 56: | ||
|- | |- | ||
|} | |} | ||
Poor prognostic factors of patients with liver metastasis include | |||
* [[Synchronous]] (diagnosed simultaneously) liver and primary colorectal tumors | |||
* A short time between detecting the primary cancer and subsequent development of liver mets | |||
* Multiple metastatic lesions | |||
* High [[blood]] levels of the tumor marker, [[carcino-embryonic antigen]] ('''CEA'''), in the patient prior to resection | |||
* Larger size metastatic lesions | |||
==References== | ==References== |
Revision as of 16:11, 9 August 2012
Colorectal cancer Microchapters |
Diagnosis |
---|
Treatment |
Case Studies |
Colorectal cancer natural history On the Web |
American Roentgen Ray Society Images of Colorectal cancer natural history |
Risk calculators and risk factors for Colorectal cancer natural history |
Editor(s)-in-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-632-7753; Elliot B. Tapper, M.D., Beth Israel Deaconess Medical Center
Overview
Natural history
Complications
Complications of colorectal cancer include:
- Intestinal obstruction
- Gastrointestinal bleeding
- Cancer spread to other organs in the body
- Cancer recurrence
- Radiation therapy side effects - skin discoloration, skin burns, headache, fatigue, hair loss, nausea, vomiting, confusion
- Chemotherapy side effects - hair loss, fatigue, weakness, nausea, vomiting, risk of infection, diarrhea
Prognosis
Survival is directly related to detection and the type of cancer involved. Survival rates for early stage detection is about 5 times that of late stage cancers. CEA level is also directly related to the prognosis of disease, since its level correlates with the bulk of tumor tissue.
5 year survival rates depending upon the stage of colorectal cancer are as follows:
Stage | 5 yr survival rate |
Stage I | >90% |
Stage IIA | 65% - 75% |
Stage IIB | 55% - 65% |
Stage IIIA | 45% - 55% |
Stage IIIB | 30% - 45% |
Stage IIIC | 20% - 30% |
Stage IV | <5% |
Poor prognostic factors of patients with liver metastasis include
- Synchronous (diagnosed simultaneously) liver and primary colorectal tumors
- A short time between detecting the primary cancer and subsequent development of liver mets
- Multiple metastatic lesions
- High blood levels of the tumor marker, carcino-embryonic antigen (CEA), in the patient prior to resection
- Larger size metastatic lesions
References