Hypoaldosteronism diagnostic criteria: Difference between revisions

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==Diagnostic Criteria==
==Diagnostic Criteria==


*There is no established [[criteria]] for the [[diagnosis]] of hypoaldosteronism. However, a positive history of [[hypotension]], [[muscle weakness]] and [[fatigue]] should raise suspicion for hypoaldosteronism.<ref name="pmid9300202">{{cite journal |vauthors=White PC |title=Abnormalities of aldosterone synthesis and action in children |journal=Curr. Opin. Pediatr. |volume=9 |issue=4 |pages=424–30 |year=1997 |pmid=9300202 |doi= |url=}}</ref><ref name="pmid10559665">{{cite journal |vauthors=Peter M, Dubuis JM, Sippell WG |title=Disorders of the aldosterone synthase and steroid 11beta-hydroxylase deficiencies |journal=Horm. Res. |volume=51 |issue=5 |pages=211–22 |year=1999 |pmid=10559665 |doi=23374 |url=}}</ref><ref name="pmid16024935">{{cite journal |vauthors=Kuribayashi I, Nomoto S, Massa G, Oostdijk W, Wit JM, Wolffenbuttel BH, Shizuta Y, Honke K |title=Steroid 11-beta-hydroxylase deficiency caused by compound heterozygosity for a novel mutation, p.G314R, in one CYP11B1 allele, and a chimeric CYP11B2/CYP11B1 in the other allele |journal=Horm. Res. |volume=63 |issue=6 |pages=284–93 |year=2005 |pmid=16024935 |doi=10.1159/000087074 |url=}}</ref>
*There is no established [[criteria]] for the [[diagnosis]] of hypoaldosteronism. However, a positive history of [[hypotension]], [[muscle weakness]] and [[fatigue]] should raise suspicion for hypoaldosteronism.<ref name="pmid9300202">{{cite journal |vauthors=White PC |title=Abnormalities of aldosterone synthesis and action in children |journal=Curr. Opin. Pediatr. |volume=9 |issue=4 |pages=424–30 |year=1997 |pmid=9300202 |doi= |url=}}</ref><ref name="pmid10559665">{{cite journal |vauthors=Peter M, Dubuis JM, Sippell WG |title=Disorders of the aldosterone synthase and steroid 11beta-hydroxylase deficiencies |journal=Horm. Res. |volume=51 |issue=5 |pages=211–22 |year=1999 |pmid=10559665|url=}}</ref><ref name="pmid16024935">{{cite journal |vauthors=Kuribayashi I, Nomoto S, Massa G, Oostdijk W, Wit JM, Wolffenbuttel BH, Shizuta Y, Honke K |title=Steroid 11-beta-hydroxylase deficiency caused by compound heterozygosity for a novel mutation, p.G314R, in one CYP11B1 allele, and a chimeric CYP11B2/CYP11B1 in the other allele |journal=Horm. Res. |volume=63 |issue=6 |pages=284–93 |year=2005 |pmid=16024935 |doi=10.1159/000087074 |url=}}</ref>
**In these patients [[Plasma renin activity|plasma renin activity (PRA)]], serum [[aldosterone]], and serum [[cortisol]] should be measured.
**In these patients [[Plasma renin activity|plasma renin activity (PRA)]], serum [[aldosterone]], and serum [[cortisol]] should be measured.
**Patients with suspected hypoaldosteronism should be also be tested for underlying conditions which can lead to decreased [[aldosterone]] level or aldosterone resistance such as [[diabetes]], [[chronic kidney disease]], [[Mineralocorticoid|serum mineralocorticoid]], [[corticosteroid]] and [[androgen]] level.
**Patients with suspected hypoaldosteronism should be also be tested for underlying conditions which can lead to decreased [[aldosterone]] level or aldosterone resistance such as [[diabetes]], [[chronic kidney disease]], [[Mineralocorticoid|serum mineralocorticoid]], [[corticosteroid]] and [[androgen]] level.

Revision as of 14:35, 1 September 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Akshun Kalia M.B.B.S.[2]

Overview

There is no established criteria for the diagnosis of hypoaldosteronism. However, a positive history of hypotension, muscle weakness and fatigue should raise suspicion for hypoaldosteronism. These patients should first be tested for serum potassium levels and later for plasma renin activity (PRA), serum aldosterone, and serum cortisol. Asymptomatic hypoaldosteronism can also be discovered on routine laboratory evaluations.

Diagnostic Criteria

References

  1. White PC (1997). "Abnormalities of aldosterone synthesis and action in children". Curr. Opin. Pediatr. 9 (4): 424–30. PMID 9300202.
  2. Peter M, Dubuis JM, Sippell WG (1999). "Disorders of the aldosterone synthase and steroid 11beta-hydroxylase deficiencies". Horm. Res. 51 (5): 211–22. PMID 10559665.
  3. Kuribayashi I, Nomoto S, Massa G, Oostdijk W, Wit JM, Wolffenbuttel BH, Shizuta Y, Honke K (2005). "Steroid 11-beta-hydroxylase deficiency caused by compound heterozygosity for a novel mutation, p.G314R, in one CYP11B1 allele, and a chimeric CYP11B2/CYP11B1 in the other allele". Horm. Res. 63 (6): 284–93. doi:10.1159/000087074. PMID 16024935.

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