Chronic myelogenous leukemia differential diagnosis: Difference between revisions
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Chronic myelogenous leukemia must be differentiated from [[leukemoid reaction]], [[chronic neutrophilic leukemia]], and [[acute myeloid leukemia]].<ref name="pmid24839370">{{cite journal| author=Gajendra S, Gupta R, Chandgothia M, Kumar L, Gupta R, Chavan SM| title=Chronic Neutrophilic Leukemia with V617F JAK2 Mutation. | journal=Indian J Hematol Blood Transfus | year= 2014 | volume= 30 | issue= 2 | pages= 139-42 | pmid=24839370 | doi=10.1007/s12288-012-0203-6 | pmc=PMC4022913 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24839370 }} </ref> | Chronic myelogenous leukemia must be differentiated from [[leukemoid reaction]], [[chronic neutrophilic leukemia]], and [[acute myeloid leukemia]].<ref name="pmid24839370">{{cite journal| author=Gajendra S, Gupta R, Chandgothia M, Kumar L, Gupta R, Chavan SM| title=Chronic Neutrophilic Leukemia with V617F JAK2 Mutation. | journal=Indian J Hematol Blood Transfus | year= 2014 | volume= 30 | issue= 2 | pages= 139-42 | pmid=24839370 | doi=10.1007/s12288-012-0203-6 | pmc=PMC4022913 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24839370 }} </ref> | ||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
Chronic myelogenous leukemia must be differentiated from:<ref name="pmid24839370">{{cite journal| author=Gajendra S, Gupta R, Chandgothia M, Kumar L, Gupta R, Chavan SM| title=Chronic Neutrophilic Leukemia with V617F JAK2 Mutation. | journal=Indian J Hematol Blood Transfus | year= 2014 | volume= 30 | issue= 2 | pages= 139-42 | pmid=24839370 | doi=10.1007/s12288-012-0203-6 | pmc=PMC4022913 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24839370 }} </ref><ref name="pmid17385676">{{cite journal| author=Kanegae MP, Ximenes VF, Falcão RP, Colturato VA, de Mattos ER, Brunetti IL et al.| title=Chemiluminescent determination of leukocyte alkaline phosphatase: an advantageous alternative to the cytochemical assay. | journal=J Clin Lab Anal | year= 2007 | volume= 21 | issue= 2 | pages= 91-6 | pmid=17385676 | doi=10.1002/jcla.20140 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17385676 }} </ref> | Chronic myelogenous leukemia must be differentiated from:<ref name="pmid24839370">{{cite journal| author=Gajendra S, Gupta R, Chandgothia M, Kumar L, Gupta R, Chavan SM| title=Chronic Neutrophilic Leukemia with V617F JAK2 Mutation. | journal=Indian J Hematol Blood Transfus | year= 2014 | volume= 30 | issue= 2 | pages= 139-42 | pmid=24839370 | doi=10.1007/s12288-012-0203-6 | pmc=PMC4022913 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24839370 }} </ref><ref name="pmid17385676">{{cite journal| author=Kanegae MP, Ximenes VF, Falcão RP, Colturato VA, de Mattos ER, Brunetti IL et al.| title=Chemiluminescent determination of leukocyte alkaline phosphatase: an advantageous alternative to the cytochemical assay. | journal=J Clin Lab Anal | year= 2007 | volume= 21 | issue= 2 | pages= 91-6 | pmid=17385676 | doi=10.1002/jcla.20140 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17385676 }} </ref><ref name="pmid24729196">{{cite journal| author=Jabbour E, Kantarjian H| title=Chronic myeloid leukemia: 2014 update on diagnosis, monitoring, and management. | journal=Am J Hematol | year= 2014 | volume= 89 | issue= 5 | pages= 547-56 | pmid=24729196 | doi=10.1002/ajh.23691 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24729196 }} </ref> | ||
*[[Leukemoid reaction]] | *[[Leukemoid reaction]] | ||
:*[[ | :*Leukemoid reaction associated with: | ||
:* [[Basophil]]s and [[eosinophil]]s are almost always increased in chronic myelogenous leukemia | ::* High [[leukocyte alkaline phosphatase]] | ||
::*White blood cell counts lower than 50 × 109/L | |||
::*Döhle's bodies in the granulocytes | |||
::*Absence of basophilia | |||
:*[[Basophil]]s and [[eosinophil]]s are almost always increased in chronic myelogenous leukemia | |||
*[[Chronic neutrophilic leukemia]] | *[[Chronic neutrophilic leukemia]] | ||
*[[Acute myeloid leukemia]] | *[[Acute myeloid leukemia]] | ||
Revision as of 20:30, 14 October 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]
Overview
Chronic myelogenous leukemia must be differentiated from leukemoid reaction, chronic neutrophilic leukemia, and acute myeloid leukemia.[1]
Differential Diagnosis
Chronic myelogenous leukemia must be differentiated from:[1][2][3]
- Leukemoid reaction associated with:
- High leukocyte alkaline phosphatase
- White blood cell counts lower than 50 × 109/L
- Döhle's bodies in the granulocytes
- Absence of basophilia
- Basophils and eosinophils are almost always increased in chronic myelogenous leukemia
- Chronic neutrophilic leukemia
- Acute myeloid leukemia
- Thrombocythemia
References
- ↑ 1.0 1.1 Gajendra S, Gupta R, Chandgothia M, Kumar L, Gupta R, Chavan SM (2014). "Chronic Neutrophilic Leukemia with V617F JAK2 Mutation". Indian J Hematol Blood Transfus. 30 (2): 139–42. doi:10.1007/s12288-012-0203-6. PMC 4022913. PMID 24839370.
- ↑ Kanegae MP, Ximenes VF, Falcão RP, Colturato VA, de Mattos ER, Brunetti IL; et al. (2007). "Chemiluminescent determination of leukocyte alkaline phosphatase: an advantageous alternative to the cytochemical assay". J Clin Lab Anal. 21 (2): 91–6. doi:10.1002/jcla.20140. PMID 17385676.
- ↑ Jabbour E, Kantarjian H (2014). "Chronic myeloid leukemia: 2014 update on diagnosis, monitoring, and management". Am J Hematol. 89 (5): 547–56. doi:10.1002/ajh.23691. PMID 24729196.