Tuberculosis future or investigational therapies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Future investigations

Principles of future investigations

Any future regimen should satisfy the following principles.

• It should not have more than a maximum duration of 6 months
• The dosing schedule must be simple
• The number of drugs in it should be ideally not more than 3-5 drug each from a different class
• It should have minimum side effect profile so that we could have minimum monitoring
• It should be effective against MDR, XDR and XXDR strains
• It should be administered per orally
• It should have minimum interaction with anti retroviral drugs.
• It should have atleast one new class of drug

New drugs involved in clinical trial for treatment of tuberculosis

Drug	Phase	Class}}
Moxifloxacin	Phase III	Fluoroquinolone
Linezolid	Phase II	Oxazolidinone
AZD-5847	Phase II	Oxazolidinone
Sutezolid	Phase II	Oxazolidinone
Clofazimine	Phase II	Riminophenazine
SQ-109	Phase II	Ethylenediamine
PA-824	Phase IIb	Nitroimidazole
Delamanid	Phase III	Nitroimidazole
Bedaquiline	Phase III	Diarylquinoline
Data provided by WHO