Sarcoidosis: Difference between revisions

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{{Sarcoidosis}}
'''Editor-in-Chief:''' Philip Marcus, M.D., M.P.H. [mailto:pmarcus192@aol.com], Division of Pulmonary Medicine
{{CMG}}; Philip Marcus, M.D., M.P.H. [mailto:pmarcus192@aol.com], Division of Pulmonary Medicine
St. Francis Hospital-The Heart Center, Roslyn, NY  
St. Francis Hospital-The Heart Center, Roslyn, NY  


'''Associate Editor-In-Chief:''' {{CZ}} and [[user:Hilary Womble|Hilary Womble, M. D.]][[mailto:hwomble@bidmc.harvard.edu]]
'''Associate Editor-In-Chief:''' {{CZ}}; [[user:Hilary Womble|Hilary Womble, M. D., Roshan Dinparasti Saleh M. D.]]
 
{{SK}} Besnier-Boeck disease;  Besnier-Boeck-Schaumann disease; Sarcoid; Uveoparotid fever; Loefgren's syndrome


===[[The Heart in Sarcoidosis|Click Here For The Chapter On The Heart In Sarcoidosis]]===
===[[The Heart in Sarcoidosis|Click Here For The Chapter On The Heart In Sarcoidosis]]===


==[[Sarcoidosis overview|Overview]]==


==[[Sarcoidosis historical perspective|Historical Perspective]]==
==[[Sarcoidosis classification|Classification]]==
==[[Sarcoidosis pathophysiology|Pathophysiology]]==
==[[Sarcoidosis causes|Causes]]==


==Image Examples==
==[[Sarcoidosis differential diagnosis|Differentiating Sarcoidosis from other Disorders]]==
 
<div align="left">
<gallery heights="175" widths="125">
Image:Sarcoid-001.jpg|Sarcoidosis
Image:Sarcoid-002.jpg|Sarcoidosis
Image:Sarcoid-003.jpg|Sarcoidosis
</gallery>
</div>
 
 
<div align="left">
<gallery heights="175" widths="125">
Image:Sarcoid-004.jpg|Sarcoidosis
Image:Sarcoid-005.jpg|Sarcoidosis
Image:Sarcoid-006.jpg|Sarcoidosis
</gallery>
</div>
 
 
<div align="left">
<gallery heights="175" widths="125">
Image:Osseous-sarcoid-001.jpg|Osseous sarcoidosis
Image:Osseous-sarcoid-002.jpg|Osseous sarcoidosis
Image:Osseous-sarcoid-003.jpg|Osseous sarcoidosis
</gallery>
</div>


==[[Sarcoidosis epidemiology and demographics|Epidemiology and Demographics]]==
==[[Sarcoidosis risk factors|Risk Factors]]==


<div align="left">
==[[Sarcoidosis screening|Screening]]==
<gallery heights="175" widths="125">
Image:Complicated-sarcoid-001.jpg|Complicated sarcoidosis
Image:Complicated-sarcoid-002.jpg|Complicated sarcoidosis
Image:Complicated-sarcoid-003.jpg|Complicated sarcoidosis
</gallery>
</div>


==[[Sarcoidosis natural history, complications and prognosis|Natural History, Complications and Prognosis]]==


<div align="left">
==Diagnosis==
<gallery heights="175" widths="125">
[[Sarcoidosis history and symptoms|History and Symptoms]] | [[Sarcoidosis physical examination|Physical Examination]] | [[Sarcoidosis laboratory findings|Laboratory Findings]] | [[Sarcoidosis electrocardiogram | Electrocardiogram]] | [[Sarcoidosis chest x ray|Chest X Ray]] | [[Sarcoidosis CT|CT]] | [[Sarcoidosis MRI|MRI]] | [[Sarcoidosis echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Sarcoidosis other imaging findings|Other Imaging Findings]] | [[Sarcoidosis other diagnostic studies|Other Diagnostic Studies]]
Image:Complicated-sarcoid-004.jpg|Complicated sarcoidosis
Image:Complicated-sarcoid-005.jpg|Complicated sarcoidosis
</gallery>
</div>


==Treatment==
[[Sarcoidosis medical therapy|Medical Therapy]] | [[Sarcoidosis primary prevention|Primary Prevention]] | [[Sarcoidosis secondary prevention|Secondary Prevention]] | [[Sarcoidosis cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Sarcoidosis future or investigational therapies|Future or Investigational Therapies]]


<div align="left">
==Case Studies==
<gallery heights="175" widths="125">
[[Sarcoidosis case study one|Case study #1]]
Image:Sarcoid-101.jpg|Sarcoidosis
Image:Sarcoid-102.jpg|Sarcoidosis
Image:Sarcoid-103.jpg|Sarcoidosis
</gallery>
</div>


==Case Examples==
==Related Chapters==
 
* [[The Heart in Sarcoidosis]]
===Case #1===
 
====Clinical Summary====
 
This 33-year-old white female was admitted for evaluation of abnormal findings on a chest x-ray. She was asymptomatic and a physical examination revealed no significant abnormalities. Laboratory results indicated hypercalcemia and elevated gamma globulin. Radiographic examination showed enlarged subcarinal, hilar, and right paratracheal lymph nodes. A right paratracheal lymph node was biopsied. Special stains for acid-fast bacilli and fungi were negative and a diagnosis of sarcoidosis was made.
 
====Histopathological Findings====
 
[http://www.peir.net Images courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology]
 
[[Image:Sarcoidosis lymph node case 001.jpg|left|thumb|400px|This is a low-power photomicrograph of a lymph node. Note the rather pale-pink color of the tissue with dark-staining cells found in only a few scattered areas. These darker cells represent the original lymphocytes of this lymphoid organ.]]
<br clear="left"/>
 
[[Image:Sarcoidosis lymph node case 002.jpg|left|thumb|400px|This photomicrograph of lymph node tissue illustrates a paucity of lymphocytes as well as numerous small, pale-staining nodules (arrows) throughout the tissue.]]
<br clear="left"/>
 
[[Image:Sarcoidosis lymph node case 003.jpg|left|thumb|400px|This is a photomicrograph of the small nodules (arrows) seen in the previous image. Close examination reveals that they are composed of large macrophages (epithelioid macrophages). These small granulomas form multiple series of reaction centers throughout the lymph node. Note the remaining lymphocytes surrounding the granulomas.]]
<br clear="left"/>
 
[[Image:Sarcoidosis lymph node case 004.jpg|left|thumb|400px|This photomicrograph of a single granuloma illustrates the individual macrophages (arrows) which make up the bulk of this tissue. There is an absence of necrosis in the center of the lesions in this case.]]
<br clear="left"/>
 
[[Image:Sarcoidosis lymph node case 005.jpg|left|thumb|400px|This is a photomicrograph of a multinucleated giant cell (1). In the center of this foreign body-containing giant cell there is a small asteroid body (2). There is no functional significance to this asteroid body.]]
<br clear="left"/>
 
[[Image:Sarcoidosis lymph node case 006.jpg|left|thumb|400px|This is a higher-power photomicrograph of an asteroid body (arrow) inside of a multinucleated giant cell.]]
<br clear="left"/>
 
==See also==
* [[Garland's triad]]
* [[Garland's triad]]
* [[Kveim test]]
* [[Kveim test]]
==References==
{{Reflist|2}}


==External links==
==External links==

Latest revision as of 08:39, 6 May 2018

For patient information click here

Sarcoidosis
Sarcoidosis in a Lymph Node.
ICD-10 D86
ICD-9 135
OMIM 181000
DiseasesDB 11797
MedlinePlus 000076
MeSH D012507

Sarcoidosis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Sarcoidosis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

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Directions to Hospitals Treating Sarcoidosis

Risk calculators and risk factors for Sarcoidosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Philip Marcus, M.D., M.P.H. [2], Division of Pulmonary Medicine St. Francis Hospital-The Heart Center, Roslyn, NY

Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [3]; Hilary Womble, M. D., Roshan Dinparasti Saleh M. D.

Synonyms and keywords: Besnier-Boeck disease; Besnier-Boeck-Schaumann disease; Sarcoid; Uveoparotid fever; Loefgren's syndrome

Click Here For The Chapter On The Heart In Sarcoidosis

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Sarcoidosis from other Disorders

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | Chest X Ray | CT | MRI | Echocardiography or Ultrasound | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case study #1

Related Chapters

External links




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da:Sarkoidose de:Sarkoidose eo:Sarkoidozo eu:Sarkoidosia he:סרקואידוזיס lb:Sarkoidos nl:Sarcoïdose no:Sarkoidose nn:sarkoidose sq:Sarkoidoza fi:Sarkoidoosi sv:Sarkoidos

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